Crown Veo in Crown Veo Rs -Detors -[PDF -Document] (2024)

Thermo Scientific Dionex

GELADEN AEROSOL -TeECTOR CORONA I see in Corona I see RS

Operating instructions (original business instructions)

Revision: 1.0

Date: July 2013

GELADEN AEROSOL -TeECTOR CORONA I see in Corona I see RS

Instructions

GELADEN AEROSOL -TeECTOR CORONA I see in Corona I see RS

Business guide Page I.

Declaration of consequences (original declaration of conformity)

Product: Thermo Scientific Dionex - Detector

Types: Corona I see and crown I see rs

Dionex Softron GmbH hereby explains compliance with the above products with the respective requirements in the following rules: • Low voltage directive 2006/95/EC • EMC Directilion 2004/108/EC

The electrical security of the products was evaluated based on the following standard: • DIN EN 61010-1: 2010

Safety requirements for electrical equipment for measurement, control and laboratory use, part 1: General requirements

The electromagnetic compatibility (EMC) products were evaluated based on the following standard: • DIN EN 61326: 2006

Electrical equipment for using EMC requirements for measurements, control and laboratory

The manufacturer is responsible for the technical CE documentation (see further down).

This statement is issued for the manufacturer

Dionex Softron GmbH DEL AF Thermo Fisher Scientific Inc. Dornierspasse 4 D-82110 Germering

Door CEO, Repelliger Obst, a Vice-PRIPRIZARD HPLC, Women's MCLCOD.

17. June 2013

GELADEN AEROSOL -TeECTOR CORONA I see in Corona I see RS

Page II Operation instructions

GELADEN AEROSOL -TeECTOR CORONA I see in Corona I see RS

Business guide Page I.

Table of contents 1 Introduction ................................................. .. ........................................................ ...... .................. 1

1.1 How to use this manual ........................................................... ................................................. ......... ................... 3

1.2.1 Symbols on the detector and in the manual ..................................... .... ............... 31.2.2 Safety rules ................................... ... ................... 41.2.3 De Sécurité ....................... .. ... ........................................................ ...... ................. 7

1.3 Intended use ........................................................... ...................................................... .... .................................................. ........ .............................................. ............ ... 111.4 Federal Communications Commission (FCC) Note ........................... ............ ............. 13

2 Overview ............................................................ ... ....................................................... ....... .................... 152.1 Description ofUnity .................... ........ .............................................. ............ ......................... 152.2 Detector configurations .......... ............. ......................................... ................. .................. 162.3 Operational principle ............ .................. .................................... ...................... ...................... 172.4 Interior front panel .. ........................ .......................... ............................ ...................... 192.5 Backpaneel .......................... ..................... ................................. ................. ....................... 202.6 Flow connections ............ ............ .......................................... ........ .............................. 212.7 nebulizer .......... ........ .................................................. ... ....................................................... 212.8 Manual gas control button (Corona Veo only).............................................. ........................... 212.10 Leoking selection ..................... .................................................... .......... ................................... 222.11 Detector display .. .......... ............................................ .............. ........................................ 222.12 Self -test diagnostics and prevention maintenance .......... ................................ .. 22

3 Installation .................................................... ... ....................................................... ................. 233.1 Facility Requirements ....................... ...... .................................................... .......... ............... 233.2 unpack the detector ..................... .......... ............................................ .............. .......... 263.3 Position the detector in aUltimate 3000 system ................ .............. .................. 273.4 connection of the rear panel of the detector ............ ............... ....................................... .......... 29

3.4.1 Overview of connections .................................................... ............................................ 293.4.2 connection of the power wire .... ................................................ .......... ....................... 293.4.3 Connect the USB cable .......... ......... ............................................. ............. ......... 303.4.4 connect the digital I/O ................... ............ .......................................... ................ .. 313.4.5 connection of the analog signal output ....................... ................. ..................... 32

4 Preparation for operation (Start -Up) ................................................. .. .................................. 334.1 Overview of promotions ........... .. ........................................................ ...... ................................334.2 Connection of drainage ...... ................................................ .......... .......................... 344.3 Connection of gas supply and exhaust pipe ...... ............ .................................. 354.4 Flow connections ............ .......................................... ................ ......................... 36

4.4.1 General guidelines ................................................. ..................................................... 364.4 .2 Capillary connection An ultimate 3000 system ....................................... 374.4.3 Installation of in -line -filter (optional) ................................................... .... ................... 384.4.4 Connection of capillaries with the detector .................. ..... .....................................39

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Page II Operation instructions

4.4.5 Connection of the current change the valve (Corona VEO RS only) .................... 404.5 Guidelines for general detector processing ............... 41

4.5.1 Mobile phase ....................................................... .... 414.5.2 Mobile phase delivery system ........................................ .................................. 424.5.3 Gastoeroer .... ............ .......................................... ................ ...................................... ... 424.5.4 Ventilation ......... .................................. .................... .............................. ............... 43

5 Operation .................................................... ... ....................................................... ....... ................... 455.1 security lines for operations ................... ........ .............................................. ............ the touchscreen ............. ...................................... ........ 48

5.3.1 Overview .................................................. ...................................................... .... .......... 485.3.2 Main menu ................................... ..... ................................................. ......... ................. 495.3.3 Run mode menu .................. ......... ............................................. ............. ................. 505.3.4 System settings menu .............. .............. ........................................ .................. ...........55

5.4 Before you control the detector ............................................. ........................................ 595.4.1 The gas pressureSet up ... ..... ................................................. ......... ......................... 595.4.2 preparation of the system......... .......... ............................................ .............. .................. 615.4.3 bilibrants of theDetector ........... .............. ........................................ .................. .... 62

5.5 Implementation of sample analysis .................................................... ........................................................ ...... .... 645.5.2 Operation of the Power Change Valve (

5.6 Optimization of the performance of the detector ............................................ ... ..................... 655.6.1 General guidelines ..................... ... ............................................................. .......... 665.6.3 Selection of evaporation temperature ................................ ......................... 665.6.4 Use of gas stream modes (only Corona Veo RS) ...... ...................................... 675.6.5 Use of a power function value ......... ............................................. ............. ........ 685.6.6 Minimize basic sound ....................... ............ ............................................... ...................... ........ 69

5.7 Internal security functions ....................................................1 Leper Detection .. .................................................... .......... ............................................ ......... 705.7.2 internally floating detection ........................................ .................. ............................... 705.7 .3 Gass system delivery Stryk Lift valve ................... ....................... ............................... .. 715.7.4 Retirement of the alarm ........... .......................... .................... ................................. ...................... 72

5.8 Closure of the detector ..................................................... ....................................................... ....... ............................... 745.8.2 Switching offlong-term ..... ......... ............................................. ............. ....................... 74

6 Chromeleon -S Software ....................................................... ..... 776.1 Set up the detector in Chromeleon ....................................... ................................ 78

6.1.1 Loading to the detector ........................................................ .................... 786.1.2 The detector installation ........................ ...................................................... .... ............ 806.1.3 Configuration of the detector ........................... ..... ................................................. ......... ... 81

6.2 Setting the detector in DCMlink ....................................................

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6.3 Operation of the detector of Chromeleon ................................................... ....................... 856.3.1 connection to Chromeleon ..................... ...................................................... .... ....... 856.3.2 Direct control .................................. .... .................................................. ........ .......... 866.3.3 automated check ........................... ........ .............................................. ............ ..... 88

7 Solving problems ............................................................ ... ... ....................................................... ........ ........ 917.1 Overview ................................. ....... ................................................... ........... ........................ 917.2 Self -test error codes ......... ............... ....................................... ......................... ............ 957.4 Business problems ........... ......................... ......................... ............................. ........... 99

8 maintenance ............................................................ ....... ................................................... ........... ............ 1078.1 security lines for maintenance ...................... ............ .......................................... .... 1078.2 returns the detector for repair ..................................... ..................... ................ 1088.3 routine and preventive maintenance ........ ..................... ............................. .......... 109

8.3.1 Inspection and service plan ....................................................... ...................................................... .... .................................................. ........ .............................................. ............ .......... 1098.3.2 HetMaintaining the detector between analyzes .................... ............ ................. 1118.3.3 Cleaning of the surface of the detector ............. ............ ..........................................

8.4 Delete leakage .................................................. ........................................................... .......................................... 1138.6 Remove from thenebulizer ........ ............................................. ............. .............................. 1158.7 Stream-Switching valve (Corona only VEO RS) .......... ........................................ ..... 116

8.7.1 Remove the valve ................................................ ..........................................1168.7.2 The valve..... .................................................. ........ ............................. 117

8.8 Replacement of the most important effects ............................................... ................................................. ......... ........... 119

9 Technical information ........................................................... ............................................... 121

10 accessories, consumables and spare parts ...................................................... ........................................................ ...... ......... 123

10.1.1 I see crown .................................................. ............................................ .............. .........................................124

10.2 Optional accessories ........................................................... ...................................................... .... .................................................. ........ .............................................. ............ .......................................... .. 12610.3 consumables and spare parts .......... ................................. ..................... .. ................ 127

11 Supplement ...................................................... ... ................................................... .................... 12911.1 Digital I/O -PIN -TAK .................. ...... .................................................. ...... ...... 12911.2 Internal Gas and Aerosolstroom Road diagram .......................... ............ ........... 132

12 Index ............................................................ ...................................................... ......................... 133

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Page IV Business Guide

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Operating instructions Page 1

1. Introduction

1.1 How to use this manual

The layout of this manual is designed to quickly refer to the sections of interest in the reader when serving Thermo Scientific ™ Dionex ™ Corona ™ VEO ™ Aerosol detector.Before the operation starts.

The descriptions of this manual apply to the following loaded aerosold detectors:

• I see crown

• Kroon I see RS

The following conventions apply to the descriptions in this manual:

• The term "detector" or "the device" is used in the manual.If some details only apply to a detector version, the version is identified by name.

• If not stated otherwise, the descriptions of Viper ™ capillary connections also apply to Nanoviper ™ and possible other Viper capillary connections.

• The detector configuration can vary.For all descriptions, your specific detector does not necessarily apply.

• The display of a part of this manual can vary from the real component.

• The descriptions in this manual refer to Firmware version 1.01.

This manual is provided "as it is".All this is done to provide full and accurate information, and all technical specifications have been developed with the greatest care.Thermo Fisher Scientific takes no responsibility for errors that can be displayed in this document that it is assumed to be complete and accurate at the time of publication and under no from using this document.In this document.

The information in this document can be changed without notification.

All rights reserved, including those for photomechanical reproduction and storage on electronic media.Road, electronic, mechanical, magnetic, manually or otherwise unveiled to third parties without the explicit written permission of Thermo Fisher Scientific Inc.

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Page 2 Processing instructions

Trademarks Empower is a registered trademark for Waters Corp.Peek is a trademark for Victrex PLC.Windows and Windows Vista is registered trademarks for Microsoft Corp.torx is a registered trademark for Textron Industries Inc.Nitronic is a registered trademark for AK Steel Corporation.simrationis a registered trademark for Carl Freudenberg KG.

All other trademarks are the property of Thermo Fisher Scientific Inc.en his subsidiaries.

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Operating instructions Page 3

1.2 Security

CE Mark -marked and Ctuvus Mark Safety Label on the rear panel indicates that the detector is in accordance with the corresponding standards.

1.2.1 Symbols on the detector and in the manual

The following security symbols are used on the detector:

Symbolic description

Changing power - Courant Alternatif

Nutrition is on (-)-L'Ostrums Est Miss Sous Tirl (-) and the food is out (o) —L'Ostrument est miss hors tension (o)

Protective group - Protective country

Complete for the business instructions to prevent the risk of damage to the operator and to protect the instrument against damage.

Label according to "Measurements for the management of pollution control of electronic information products" (China RoHS) Directive Étiquette "Measures to manage the pollution control of electronic information products" (China Rohs)

WEEE (Waste Electric and Electronic Equipment) Label for more information, see the WEEEE-INCOM Section in "Installation and qualification for chromatographic instrument". Thise ethics (electrical and electronic equipment waste)-consult the weee information chapter in the Weee information chapter "Installationand qualification and qualification for chromatographic instrument ".

Messages of special interest are indicated with certain symbols at various points in the manual:

Tip: Indicates general information and information intended to optimize the performance of the device.

Important: indicates that not complying with the corresponding information can cause incorrect results or lead to damage to the device.

Important: indicates that the attached information is not taken into account can lead to false results or damage the instrument.

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Warning: indicates that non -compliance with the corresponding information can lead to personal injury.

Warning: indicates that the attached information is not taken into account, can cause physical damage.

1.2.2 Safety rules

Tip: Before the first operation of the detector you must familiarize yourself with the content of this manual.

See page 7 for the safety conditions in French.

Warning: All users of the device must meet the following safety conditions and all additional safety conditions in this manual to prevent the possibility of personal injury or damage to the device when serving the device or performing maintenance or service procedures.

View any warning tags on the device and see the related sections of these operating instructions.

• Protective equipment When performing any work on or near the HPLC system, you wear personal protective equipment (protective clothing, safety gloves, safety glasses) as required by the danger of the mobile phase and the sample.Consult the material safety data magazine for the guidelines of Good Laboratory Practice (GLP) for advice on specific dangers.

A glove facility and a sink must be close to the unit.

• Hazardous substances Many organic solvents, mobile phases and samples are harmful to health.Data sheet (SDS).

Throw waste away in an environmentally friendly way in accordance with all local regulations.Tillad Non -Forte, toxic and/or contagious substances to accumulate.A regulated, approved program for waste removal.The municipal sewer system.

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Operating instructions Page 5

• Dangerous gases install the HPLC system in a well-ventilated laboratory.Avoid open flames and sparks.

The exhaust gas can contain dangerous fumes.

• Electrostatic discharge of electrostatic energy can lead to sparks and can form a fire hazard.

Take appropriate measures to prevent the generation of static electricity in the vicinity of the HPLC system.For example, it is that the humidity level in the laboratory is sufficiently high and offers the correct ventilation, carries anti -static clothing or shoes, preventing the accumulation of air bubbles in waste lines and the use of grounded waste containers.Only non-unique capillaries to steer solvents in the waste bin.

• Self -approach to solvents does not use solvents for which the self -antagetic temperature is lower than 150 ° C. In cases of leakage, these solvents can itself on a hot surface.

• Capillaries, capillary connections, open connections ♦ Capillaries, especially non-metal capillaries can blow up, slide out of their fittings or

May not be screwed. This can lead to substances spraying from the open connections.

♦ In an ultimate 3000 system, some components are made of Peek ™.THF).

♦ Do not use pipes that are stressed, curved, cracked or damaged.

♦ Capillary connections can be contaminated by harmful substances or harmful substances can escape open connections.

♦ Always wear safety glasses when handling melted silicon tubes, for example during installation or when cutting capillaries in length.

• Disconnect the detector from all power sources before removing the panels.When the panels are removed, dangerous electrical connections are exposed.

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• Always replace inflated fuses with original spare parts Lighting approved by Thermo Fisher Scientific.

• Replace defective communication cables.

• Replace defective network lines.Never use a streamline other than the streamlines that are available for the device.

• Only use the original spare parts and accessories that are permitted with the unit of Thermo Fisher Scientific.

• When operating the HPLC system you always set a lower pressure limit for the pump.

• To prevent damage to the detector when lifting or moving, always lift the device at the bottom or sides.

• After surgery, buffers and solutions that form peroxides are flushing.

• Before switching from buffer to organic solution, rinse the analytical system thoroughly with Deeonized or HPLC quality water.

• When switching to another solvent, make sure that the new solvent is miserable with what is included in the HPLC system.

• If a leak occurs, switch off the detector immediately, stop the pump current and clarify the situation.

• Only use standard solutions (HPLC quality) and buffers that are compatible with all parts that can be exposed to solvents.

• Before you boss the operation for several days or more, or when preparing the detector for transport, you must observe the precautions to close the detector (→ page 74).

• Do not use the detector in other ways than it described in these business instructions.

• Keep the business instructions close to the device to be available for quick reference.

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Operating instructions Page 7

1.2.3 Safety instructions

If you use analytical instruments, you must know the risk of chemicals.

Note: Before using the instrument, make sure that you are familiar with the content of this manual.

Warning: All people who use the instrument must observe the following security instructions to prevent you from bringing your person or damage to the instrument during use and maintenance operations.

View the warning tags on the instrument and see the corresponding sections of this user manual.

• Protective equipment for all work on HPLC or nearby system, bears the personal protective equipment (protective clothing, safety gloves, glasses) that correspond to the risks that occur as a result of the mobile phase and/or 'sample.Correct processing of connections and recommendations for specific risk situations, please contact the safety data sheets of the substances you use..

• Hazardous substances with many organic solvents, mobile phases and samples are harmful to health.Substance you should treat it as if it contained a potentially dangerous substance.In an ecological way in accordance with the applicable rules at the local level.

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• Dangerous gas installs the HPLC system in a well -invented laboratory.Should avoid naked flames and flowers of sparks in the neighborhood.Exhaust gas can contain dangerous broadcasts.

• Electrostatic discharge electrostatic discharge can lead to sparks being formed and a risk of fire can be a risk.).Only use non-commanders to send solvents to the waste tank.

• Spontaneous inflammation of the solvents does not use solvents with a temperature of self -inflammability of less than 150 ° C, if a leakage occurs, these solvents can be in contact with a hot surface.

• capillaries, hair jackets, open connections ♦ Capillaries, especially non-metal capillaries, can split or

Sliding plugs or cannot be sewn.

♦ In an ultimate 3000 system there are some components of the look.Although this polymer has excellent chemical resistance to most organic solvents, it is usually blown up when it is in long -term contact with chloroform (CHCL3), sulfoxide dimethyle (DMSO) or tetrahydrofu (THF).Moreover, it is attacked by concentrated acids, such as sulfuric acid and nitric acid or a connection of hexane, acetatethyl and methanol.

♦ Do not use ground, folded, damaged or damaged capillaries.

Dangerous or hazardous substances can come from open connections.♦ Wear glasses when handling

Fondue (under installation, cutting, etc.).

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Operating instructions Page 9

• When the protective caps of the device are dismantled, you will be exposed to electrical connections with the highest time available.

• Always replace grilled fuses with reserve securities approved by Thermo Fisher Scientific.

• Replace the defective communication cables.

• Replace the defective mesh lines.Only use the electric grid lines that are specific for the instrument.

• Only use original spare parts and accessories approved by Thermo Fisher Scientific.

• Always set a minimal pressure limit for the HPLC pump.

• Always keep it under or from the sides of the device when lifting or the instrument.

• Probably clean the system after use with stamps and form peroxides.

• When you go from a saline solution to an organic solvent, you perform an intervening rinse of the HPLC system with theianized water or HPLC quality.

• If you go to another solvent, make sure that the new solvent is in the pump.Ear the pump can be damaged;

• If a leak occurs, stop the instrument immediately, stop the pump current and dissolve the problem.

• Only use solvents (HPLC quality) and saline solutions that are compatible with the materials exposed mobile phase.

• Many organic solvents and saline solutions are toxic.

• Before you disconnect the operation for a few days or longer, you must see the precautions that appear on page 74.

• Use the other instrument not different than it described in this manual.

• Keep this manual close to the instrument to consult it easily.

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Operating instructions Page 11

1.3 Intended use

The device is designed to be served only qualified and authorized staff.All users must know the dangers of the device and the medicines used.

The detector is only designed for the use of laboratory tests in high -quality liquid chromatography (HPLC) or Ultrahøj Performance Fluid Chromatography (UHPLC) applications.Sufficient control entries and output available.

The detector can be controlled by Chromeleon ™ chromatography management system, but can also be operated with other data systems, such as

• Xcalibur ™.To do this, the DCMlink (Thermo Scientific Dionex Chromatography is mass spectrometry -link required in addition to the installation of the data system.

• Empower ™.To do this, the installation of Thermo Scientific Dionex instrument Integration software is required in addition to installing the data system.

For information about the availability of these and other data systems, contact Thermo Fisher Scientific Sales Organization for Dionex HPLC products.

View the following when using the detector:

• The detector may only be operated with original accessories and spare parts as recommended by Thermo Fisher Scientific and within the technical specifications (→ Page 121).

• Only use standard resolutions of at least HPLC quality or better solvent quality that is compatible with all parts of the system that can be exposed to solvents.121).For information about the moistened parts of the other Ultimate 3000 -System modules, see the 'Technical Information' section in the business instructions for the ultimate 3000 modules.

• Only use volatile organic buffers.

• Pay attention to the special properties of solvents such as fishing, boiling point, UV absorption (UV/fish detector), refractive index (refractive index detector), resolved gas (Degasses) and pH value.

• Moreover, read the information about the compatibility of solvents, buffer concentrations and mobile phase requirements in the other system modules.

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Page 12 Processing instructions

If there is a matter of appropriate use, contact Thermo Fisher Scientific before continuing.

Warning: If the device is used in a way that is not specified by Thermo Fisher Scientific, the protection of the device can be reduced.Thermo Fisher Scientific assumes no responsibility and is not responsible for damage to the operator and/or instrument damage.Probably, the fact that the protection is reduced, the instrument must be disconnected from all power sources and be protected against any deliberate operation.

Warning: If the instrument is used in an undisturbed way by Thermo Fisher Scientific, the instrument can be offered.Protection of the instrument is never guaranteed at any time, disconnect the instrument from all power sources and ensure that the instrument is not used involuntarily.

Referred

In addition to this manual, it may be necessary to obtain information from other documents to modules that you use with the detector.

• Operating instructions to the other modules in your system

• Chromeleon 6.80 Chromatography Management System helps documents

• If applicable business instructions for the gas supply (for example nitrogen generator)

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Operating instructions Page 13

1.4 Opmerking Federal Communications Commission (FCC)

This equipment has been tested and proved to meet the boundaries of a digital unit in class A in accordance with part 15 of the American FCC rules.These limits are designed to offer reasonable protection against harmful interference when the equipment is used in a commercial environment.Case The user is obliged to correct interference in his account.

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2 Overview

2.1 Description Description

The detector is a modern high-quality instrument designed for HPLC, UHPLC and MicrolC analyzes, especially as part of the ultimate 3000 system.

• The detector uses charged aerosold detection (CAD) technology for liquid chromatography.

• The analyzed connection does not have to have a Chromofor, as is the case with the UV detection.

• The detector offers great sensitivity and a wide dynamic interval.Under Isocratic circ*mstances, non-volatile analysts produce a similar response, regardless of the chemical structure.

• Sampling fast data ensures full compatibility with HPLC and UHPLC applications.

• The concentric design of the Focus Jet ™ Nebulizer offers an extensive flow speed area.

• Checking the detector using chromeleonchromatography management system offers a high degree of system integration and maximum analysis -efficiency due to extensive data analysis and evaluation functions in Chromeleon.

• All parts that can be exposed to solvents are made from materials that offer optimum resistance to the most used solvents and buffer solutions in HPLC.

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2.2 Detector configurations

The detector is available in the following configurations:

Description part nr.

Kroon I see 5081.0010

Corona Se Rs 5081.0020

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Operating instructions Page 17

2.3 Operations Principle

The operational principle of the detector is based on loaded aerosold detection..

Fig.1: schematic drawing of the operational principle

No.begoing nr.be deregins

1 mobile phase and analyte from column 6 evaporation pipe

2 Atomizer 7 Blend Chamber

3 Gas inlet 8 ion beam inlet

4 Spray Chamber 9 Ion Trap

5 Via the drainage to waste 10 electricometer

The mobile phase with the Analyt is aware of the column ( # 1) and is introduced in the nebulizer (no. 2) .Prykgas ( # 3) is introduced by the integrated gas filter.) is the mobile phase with the analyte that is inherited to an aerosol using the printing gas.Store aerosol drops are removed from the detector with the drain pump ( # 5).

The resulting fine aerosol drops go through the evaporation pipe ( # 6) that remove the solvent and more volatile components.Formed when nitrogen is over a corona line.

4 2

9 10

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Page 18 Business instructions

Excess load is removed in surplus load of ion trap., The greater the load they can wear and the greater the response the detector measures.

See section 11.2 (→ Page 132) for a graph of gas and aerosol stream paths in the detector.

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Operating instructions Page 19

2.4 Inner front panel

The detector is designed to offer easy access to the inner front panel.Cover on the right side of the front panel to gain access to the detector inlets and leaks.

Fig.2: The front view of the detector (here: Corona Veo RS)

No description

1 LED 'Power' LED is blue when the detector is switched on.

2 View with integrated touch screen with: - General information - detectormenu and settings

3 Slots capillary

4 Focusjet nebulizer When the detector is sent, no injector is installed.

5 Corona Veo Rs Only Power Change Falp

6 Lexensor

2 4

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2,5 bagpanel

Fig.3: Bagpanel (Haar: Corona Veo RS)

No description

1 fridge fan

2 Gas connections

Any reward

2b gascas

2c Corona VEO Only manual gas control button (a plug has been installed instead for Corona VEO RS.)

3 Digital I/O consisting of 2 terminals with TTL inputs and relay outputs for connection with external devices.

4 Fuse protection contains two slow fuses that are classified to 1 a (5 x 20 mm).

5 main stream container

6 Power Switch

7 Analog signal output (optional) installation option to connect a suitable coaxial cable.

8 USB port (USB 1.1 and 2.0 compatible) to connect the detector to the data system computer.

9 Protective grounding indicates the functional soil connection.

8 7

everyone

ver

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Operating instructions Page 21

2.6 Flow connections

The detector is designed to offer easy access to capillary and pipe connections.system.

Tip: The Stroompad between the column and the detector must be as small as possible (shortest possible capillary connection) to prevent the peak supply effects and the corresponding loss of chromatographic efficiency.

2.7 Dress

The detector is sent without a renewal being installed.

Focusjet concentric injector is the liquid inlet of the detector.

2.8 Manuel Gas Regulatorknap (Kun Corona I see)

The Corona Veo detector is equipped with a manual gas regulator.

2.9 Stream-Switchingventil (Kun Corona Veo Rs)

Corona VEO RS is equipped with a 6-poort 2-position Power Change Valve (SSV).SSV can be used to send the power to the nebulizer or to manage to external units or waste.

See section 4.4.5 (→ Page 40) to connect the valve of the power change.

See section 5.5.2 (→ Page 64) For more information about the operation of the Power Change valve.

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Page 22 Operating instructions

2.10 Lexensor

A leak hat is located in the drop bin on the right side of the front panel of the detector for the automatic detection of liquid leaks.A warning code appears on the display.

Tip: If you operate the detector from a chromatographic data system, a warning code is also documented in the Audit Tracks of the software.

When the Lekmolder reports a leak, remove the cause of the leak and dry the leak (→ page 112).

2.11 Detector display

The detector is equipped with a liquid crystal color display with integrated touchscreen that is designed for simple menu navigation.

See section 5.3 (→ Page 48) For more information about the Display and Detector menu.

2.12 Self -test diagnostics and preventive maintenance

The detector supports several benefits and reliability functions:

• Self-test diagnostics by power-up (→ Page 47)

• Preventive maintenance (→ Page 109)

• Lexensor (→ Pagina 70)

• Internal liquid sensor (→ page 70)

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3 Installation

3.1 Requirements for facilities

In addition to the facility requirements and the security information below, you must observe the precautions in section 1.2.2 (→ page 4).

Website -Requirements

The installation site must meet the following requirements:

• The main switch and the most important power vessel are on the rear panel.

♦ Free and unlimited access to the main switch is protected at all times.

♦ The network cord of the unit can easily be reached and disconnected from the streamline.

• The installation site must meet the electricity and environmental specifications stated in the 'Technical Information' section (→ section 9, page 121).

• Install the detector in the laboratory on a stable, flat surface that is free from vibrations.

• The detector must have approximately.65 cm linear bank space.

• Ensure that the surface can withstand solvents.

• Avoid placements with extreme temperature changes, such as ventilation openings or placements with air designs almost by air.

• Avoid locations with direct sunlight and high humidity.

• Allow sufficient approval and on the sides of the detector for easy access to power connections, the main switch, gas connections and ventilation.

• Install the detector in a place that offers access to an outlet, near gas supply and ventilation sources.

• An uninterrupted food (UPS) may be needed for electric lines that are susceptible to large power fluctuations.

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• Connect the detector with an electric line that shares a common plot with other system modules.If necessary, use a well -functioning multiple socket.noise).

Warning: Do not use defective multiple sockets or extension cords because they can cause personal injury or damage to the device.

Warning: Do not use defective multi -powerful blocks or extensive cables.This can cause physical damage or damage the instrument.

Ventilation requirements

• Ventilation must be on atmospheric pressure without vacuum or negative pressure exerted.

Important: a vacuum in ventilation can cause the pressure in the detector.

Important: a void of ventilation can lead to the pressure within the detector.This can damage the correct function of the detector and contribute to a reduction in performance.

• Install the HPLC system in a well-ventilated laboratory.The gas outlet to a smoke hood or other ventilation and the detector is correctly ventilated.

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GASS Supply requirements

Important: To prevent damage to the detector, the maximum gas pressure of 550 kPa (80 psig) does not exceed the gas supply.

Important: Do not exceed a maximum gas pressure of 550 kPa (80 psig) for gas supply.

• If you work with flammable solvents, use nitrogens.Nitrogen with a higher purity is not required, but must be dry (not contain water vapor).Before entering the detector.The use of a well -filtered company stock can increase the basic noise.

• View the following comments:

♦ input gas must be clean and free of microdelticles (size ≤ 0.1 um).

♦ Input gasting pressure pressure must be between 480 - 550 kPa (70 - 80 psig).

♦ The gas consumption of the detector is approximately.4 l/min.

• Pressure variations in which the gas supply falls under 480 KPA (70 PSID) can lead to loss of performance during installation.

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3.2 Unpacking the detector

All electrical components of the detector are carefully tested before the module is sent from the factory.

Tips: Report any damage to both damage to both, the incoming courier and Thermo Fisher Scientific.

Keep the original shipping container and gasket material.It offers excellent protection of the module in the event of future transit.

1. Open the detector's packaging box and remove the accessory set and the main courses.

The range of delivery includes:

♦ Detector

♦ Kit accessory

♦ Nebulizer

♦ Power connecting cable

♦ Business instructions

2. Take the detector on the sides.Long and careful, pull the detector from the shipping container and place it on a stable surface.

Important: To prevent the detector from falling, you must understand the detector on the sides and then lift the detector together with the foam distance from the shipping container..

Important: To prevent the instrument from falling, enter it on the sides.Do not lift the instrument E with the packaging material or at the doors of the front panels.

3. Remove the foam resident and then remove the polyetheen package.

4. Before the module connects the detector to the food source, the module must be at room temperature and allow any condensation that can evaporate during shipment.

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3.3 Location of the detector in an ultimate 3000 system

If the detector is part of an ultimate 3000 system, for example for analytical HPLC applications, light the individual modules and connect them to the rear panel as shown in the example in Fig.4.

Solvent stand (optional)

Pomp

Auto-sampler

Column space

Detector

Fig.4: Example for stacking and connections of the rear panel in an ultimate 3000 system with the Corona VEO RS detector

View the following when you place the detector:

• The set -up of the system modules depends on the application and can vary if an optical detector is further used.

• Place the detector in a position so that the connections between the exit of the column and the inlet of the detector are minimized.

• In an ultimate 30000 system, apart from the solvent standard, all system modules can be connected to the computer separately via the USB port on the rear panel on the module.To the computer with only one connection.

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Services with series and parallel detector configuration detector can be used in series or parallel configuration with other detectors (for example a UV detector or mass spectrometer).

Series Configuration In Series Configuration, a power path of the pump is used for every type of detector that is installed on the system.

• In general, charged aerosol dentists, such as the Corona Veo detector, must be placed in the system at the end of the Stroompad.

• The addition of other detectors can contribute to the expansion of the tape and have a negative effect on the maximum form measured by the detector.

Parallel configuration in parallel configuration with another detector or mass spectrometer, consider the following:

• Use a power splitter to guarantee a balanced distribution of liquid flows to each detector in the system.

Tip: Thermo Fisher Scientific recommends using an adjustable analytical power split (part 70-6377, adjustable from 1: 1 to 20: 1) to flexible, accurate and accurate liquid flow.

• If you use a passive power split device and therefore adjust the liquid flows (balance), consider the back pressure of the detector.Complete the flow rate specifications in the 'Technical Information' section (→ section 9, page 121).

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3.4 Connect the rear panel of the detector

3.4.1 Overview of connections

Back panel connections depend on the system configuration.

• USB connection Connect the USB port with ♦ Use the detector with other system modules such as ultimate 3000 modules.- and/or -♦ Connect the detector via a USB port

Chromatography software such as Chromeleon.

• Digital I/O connection connects the digital I/O port with ♦ Connect a pump to the detector within an HPLC system such as the ultimate 3000

System and place the 'pump -off' connection. and/or - ♦ Connect the detector to other external devices.

• Analog signal output connection and install the analog signal output to use the detector with a computer computer computer if there is no USB port on the computer.

3.4.2 Connect the network cord

Use the electricity line that has been sent to the device to connect the detector to the main source.

Warning: Never use a different power cord than the streamlines delivered to the device.

Do not use defective multiple sockets or extension cords because they can cause personal injury or damage to the device.

Warning: only use the electrical streamlines that are specific to the instrument.

Do not use defective multiple blocks or extensive cables.This can cause physical damage or damage the instrument.

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3.4.3 Connecting the USB cable

Connect the detector to the computer computer via the USB port on the rear panel.

The next cable is available (delivered in the accessory kit at the detector):

USB cable part no.

USB cable, type A for type B, high speed, USB 2.0 compatible (cable length: 3 m) 70-5713

Tip: USB standard limited USB cable length up to 3 meters.

The following connection options are available:

• Connect the detector directly to the USB port on the computer.

• If you use the detector in an ultimate 3000 system, connect the detector with an internal USB hub on the pump in the ultimate 3000 series (except LPG-3400XRS pump*).Connect the system via only one connection to the computer.If the system contains a UV detector outside the detector, you must connect the UV detector directly to the computer.* LPG-3400XRS pump is not equipped with a USB hub.

Tips: It is not possible to use the USB hub on the ultimate 3000 autosampler to connect the detector with the computer.

The detector does not have a USB hub on the rear panel.It can therefore only be connected to USB hubs from other modules in the ultimate 3000 system or directly on the computer.

• To operate the detector of the chromeleonchromatographic software, Chromeleon checks that the computer is installed and the license code is entered before the detector is connected to the USB port of the Chromeleon computer and teeth for the detector capacity.To the detector automatically and the Windows® operating system, the detector can detect on power-up.

See section 6 (→ page 77) for more information about Chromeleon edits.

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3.4.4 Connect the digital I/O

General Information

The detector is equipped with two digital I/O terminals for connection with external devices (such as an autosampler, a data station, pumps, valves, etc.) that can synchronize their function.3 relay outputs).

Digital I/O -Terminal A includes 2 relay outputs and 1 TTL -input, and digital I/O -Terminal B comprises 3 TTL inputs and 1 relay output.

Use a suitable cable, such as I/O 2-guide cable (part no. 70-4850) to connect an external device to the rear panel to the rear panel./O -the functions on the device that you want the detector.

Connect wires with terminal ports:

1. Find the screwdriver (size 3/32 "x 2") from the accessory to the detector.

2. Open the screw on the rigid that you want to connect a cord with the screwdriver.

3. Place the loose cord in the pen.

4. Close the screw on the pen.

See section 11 on page 129 for information about the functions of the connecting founders and PIN allocation of the detector.

'Pump off' output connection

The digital I/O port on the rear panel of the detector includes a special 'pump from' output to a pump within an HPLC system such as the ultimate 3000 system.Detector a safety function has been established.

Note the following:

• To use this security function, the support relay on the pump must be designed to stop the digital I/O functions of the liquid.IO.

• Corona VEO RS Only the power-changing valve on the Corona VEO RS detector has an integrated safety function.In cases of a failing of the gas supply, the power change valve will automatically distract the liquid flow from the detector.

Thermo Fisher Scientific recommends that you always connect the 'pump from' output on the pump within an HPLC system.

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See Chromeleon AID for information about connecting an LPG-3400XRS pump for more information about connecting an LPG-3400XRS pump with the output of the 'Pump Off' output.For the LPG-3400XRS pump.

3.4.5 Connection of the analog signal output

The analog signal output has a signal of 0-1 V that is proportional to the measured current.Output uses a BNC connector (Bayonet Neill-Concellman).

See the installation instructions in the analog signal output set for information about the installation and connection of the analog signal output.

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4 Preparation for operation (Start -Up)

4.1 Overview of promotions

After you have been unpacked, placed and connected to the detector as described in paragraphs 3.1 to 3.4 (→ page 23 and the following), prepare the detector for operation.

1. Connect the drain pipe as described in section 4.2 (→ Page 34).

2. Connect the gas pipes to the gas inlet and gas exhaust as described in section 4.3 (→ Page 35).

3. Install the injector as described in the installation instructions for the nebulizer.

4. Make the power connections of the detector with the other modules in your system as required by your application.

5. Switch on the detector.Complete the notes and precautions in section 5.2 (→ Page 47).

6. Chromeleon installation (optional) When the display shows the main menu after the self -test, set the detector in Chromeleon as described in section 6.1 (→ page 78).

7. If necessary, the brightness of the detector screen will be adjusted (→ section 5.3.2, page 49).

8. Set the date and time on the detector screen if necessary (→ section 5.3.4.2, page 57).

9. Set the gas pressure for the nebulizer as described in section 5.4.1 (→ Page 59).

10. Before using the detector for sample analysis, prepare the LC system and the detector as described in sections 5.4.2 and 5.4.3 (→ from page 62).

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4.2 Connection of drainage

The detector has two drainage ports at the bottom right of the housing to collect liquid leaks or waste from the detector.

FIG.5: DrainagePage

No description

1 leak door for liquid leaks of the drip drawer.

2 Waste gate for liquid from the drain pump during the company.

When connecting the drainage gates of the detector, view the following:

• Connect ports separately with a drainage plan for each port.Do not use a connecting pipe to connect both ports.

• Both drainage gates can be directed to the same waste.

• Use the elbow and t -shirt from the accessory to the detector to connect the drainage gates.

• Make sure that the hose and waste bottle is below the amount of the detector.

Drengen in an Ultimate 3000 system in an ultime 3000 system You can use the components of the drainage set to ultimate 3000 systems to steer liquid leaks to waste via the drain system.

If there is more than an ultimate 3000 detector in your system and you need an extra T -piece piece, you can find one in the accessory kit in the ultimate 3000 fluorescence, multiple wavelength or diodearray detector.

2 1

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4.3 Connection of gas supply and exhaust pipe

Connect the gas and exhaust pipe of the accessory to the gas inlet and the exhaust outlet at the back of the detector.Complete the gas requirement and warning statements in section 3.1 (→ page 23) and the guidelines for gas supply and ventilation in sections 4.5 .3 and 4.5.4 (→ from page 42).

If necessary, use the hose cutter of the accessory to cut the hose to the correct length.

Tip: Make a straight sliced perpendicular to the length of the gas inlet pipe for a good connection for push-in-mounting on the gas inlet.

If you want to use a different gas inlet pipe with metric dimensions, you can use the empty-to-with-with-with-with-adapter of the detective style package to connect the hose to the gas inlet of the detector.

1. Find the gas inlet pipe (part no. 6081.1070) and the exhaust pipe (part no. 70-6261) from the accessory kit to the detector.

2. Connect one end of the gas inlet pipe to the push-in-mounting on the gas inlet of the detector.

3. Connect the exhaust outlet:

A) Connect one end of the exhaust pipe to push the outlet outlet of the detector.

b) Connect the other end of the exhaust pipe to a flue or other ventilation unit source.

Warning: The exhaust gas can contain dangerous fumes.

Warning: Exhaust gas can contain dangerous fumes.

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4.4 Make flow connections

The following section contains information about connecting capillaries with your detector.

4.4.1 General guidelines

When connecting capillaries with the detector, view the following general precautions:

• View the precautions for capillaries and capillary connections in section 1.2.2 (→ page 4).

• When connecting capillaries, make sure that the plugs are free of pollutants.Even small particles can cause damage to the system.

• Only use the capillaries that have been sent with the detector or original spare ties.

• Always make sure that the ID for the replacement capillary matches the ID of the capillary sent with the system.

• Make sure that the plugs and capillary ends are free of pollutants and not damaged.

• The connection between the column and the detector must be as short as possible to prevent tape crashing.

See section 10.2 (→ Page 126) for more information about the available capillaries.

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4.4.2 Capillary connections in an ultimate 3000 system

Note the following:

• Different mounting systems are used in an ultimate 3000 system.That is why they are installed capillaries and fittings in the positions for which they are intended.

• Viper and Nanoviper bowel connections only loosen the Viper connectivity with the black driven screw and only with your hand (do not use tools).Leakage on the connection, you have to fast the screw for a little longer.Replace the capillary of Viper.

When connecting Viper's capillaries, view the guidelines in the installation instructions that were sent with the capillary.

Capillaries with Viper -mounting connections can also be reused for a different connection.

• Conventional confirmation connections (non-Viper) do not produce these assembly connections.

If there is still a leak, consider first cleaning the connecting gate with a cleaning (part no. 6040,0006).

Recycling used fittings and ferules only with the same capillary connection.

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4.4.3 Installation of in-line filter (optional)

An in-line filter is included in the accessory skirt for detector. In-line filter can be used in the Stroompad before the detector to prevent particles from entering the nebulizer.

To install in-line filter:

1. Search and Extraheer in-Line filter.in-line filter is sent with a filter-free.

2. Open the last two nuts in the filter unit.

3. Rinse the filter housing with awarded water.

4. Install and close one nut.

5. Place the filter in the filter housing.In order of filter -free is correctly centered and sitting against the surface of the final nut.

6. Install the other final nut and tighten it carefully until the switch between the cap and the filter is marked.-Tht.

7. Connect the in-line filter to the system current as described in section 4.4.4 (→ Page 39).

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4.4.4 Connection of capillaries with the detector

To connect the detector to the system flow:

1. Find the red capillary and reflex fittings of the accessory dirt to the detector.

2. Connect one end of the red capillary to the column exhaust using a mounting.

3. If you use the in-line filter

A) Connect the capillary of the column output to the electricity end of the in-line filter.Ensure that the flow direction is indicated on the filter housing.

b) Rinse the in-line filter with a mobile phase with a flow rate of approximately 5 ml to waste.

c) Connecting a capillary to the power-reducing end of the in-line filter.

4. Remove the white lid on the right side of the detector.

5. Connect the other end of the red capillary with the liquid inlet of the detector using a mounting.

♦ Corona VEO: Connect the capillary to the nebulizer.

♦ Corona VEO RS: If you use the Power Change valve: Connect the capillary to the input port (port 3) on the power change valve.

If you do not use power, change the valve: Connect the capillary to the nebulizer.

After you have made the capillary connections with the detector, you can reinstall the white cover on the front panel.

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4.4.5 Connection of current change changes the valve (Corona Veo RS only)

To connect the power change valve, you must connect ports 2, 3 and 4 of the valve.

Hair.porte

2 Rediriger/Waste (away from the detector)

3 inlet (capillary from column)

4 Atomizer (for attress inlet)

Fig.6: Ports on Power Shift -Klep

1. Make sure you have connected the detector with the Stroompad as described in section 4.4.4 before continuing.

2. Find the Viper Capillair, the gray capillary and Rheflex fittings of the accessory dirt to the detector.

3. Connect the Viper capillary of the injector (port 4) with the power change valve with the nebulizer inlet with the help of Rheflex fittings.

4. Connect the gray capillary to the diversion/waste port (port 2) using a Rheflex assembly and aim it to the waste.

1 2

4 5

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4.5 General guidelines for detector processing

The following sections offer general guidelines for detector processing.

4.5.1 Mobile phase

Quality for mobile phases significantly influences detection limits and detector performance.phase with the detector.

To guarantee the optimum performance of the detector, take the following guidelines:

• Prepare all mobile phases with HPLC quality (or better) solvents and reagent lime chemicals.

Tip: It is recommended to use water from an Ultra-Interest-Deïonized Source, which usually has a low conductivity and high resistance.

• Only use mobile phases that contain water, solvents and adjust the reagents of the highest available purity.

• The stability of the mobile phase can fall for a certain period.

Tip: It is recommended to use Degasses for HPLC systems online with the detector.In some cases it may be necessary to use helium distribution and/or noise treatment in the preparation of the mobile phase to achieve optimum results.

• Ensure that non-fighter particles and/or additives from the mobile phase minimize.

• Use solvents with at least residue after evaporation.If a certain solvent causes problems as a result of particles, you can try a different character or supplier.

• When switching a buffer to another operational mobile phase, make sure that the solvents are mixable and do not cause rainfall from the buffers.

• Only use volatile additives for mobile phase (buffers, solvents, etc.).

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The following table is to help you with typical additives and buffers.

Additive/buffer pka -puffer gebied

Trifluoreddikesyre (tfa) 0,3

Aryzuur 3.75 2.8 - 4.8

Ammoniumformat 3,75 2.8 - 4.8

Acetic acid 4.76 3.8 - 5.8

AmmoniumaCetat 4.76 3.8 - 5.8

• Exposure of the detector for non-fuchs salts will lead to increased background flows and noise.Remove salts from the detector.Undg to use inorganic buffer salts.

• Use nitrogen with very flammable mobile phases such as tetrahydrofuran (THF) and other ethers or ketones.

4.5.2 Mobile follow -up system

The pump must deliver a continuous current and at the same time ensure that the mixture of the mobile phase (if the gradient is used).

However, the mobile phase reservoir must be glass.In some applications, however, it may be necessary to use plastic solvent reservoirs.

4.5.3 Gastoevoer

• The gas supplied to the detector must be air or nitrogen.Always use nitrogen with tetrahydrofuran (THF) or other very flammable solvents.

• If nitrogen gas is used, this must be clean (usually ≥ 95 %), free of particles and may not contain volatile hydrocarbons or solvent lights (eg compressor oil).

Tip: If necessary, use a submicron filter in combination with a water captain beer close to the nitrogen gas source.

• The gas supplied is filtered by a carbon filter and a high -efficiency particle -shaped air filter (HEPA) in the detector.Make sure that filters are correctly maintained to guarantee optimum gas quality.

• If you use a nitrogen generator, observe the manufacturer's user documentation with recommended service intervals for the generator to offer the optimum performance of the detector.

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4.5.4 Ventilation

Important: volatile hydrocarbons, such as compressor oils in the external gas supply to the detector, can cause permanent damage to the detector.

Important: volatile hydrocarbons, such as compressor oils in external gas supply, can cause permanent damage to the detector.

• Maintain a well -invented laboratory.

• Only work the detector when the outlet valve is properly connected.

• The use of a bottle or liquid nitrogen cylinders can be a fast and easy source of nitrogen during installation.

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5 Operation

5.1 Effect security guidelines

English security guidelines

See page 46 for the security guidelines in French.

Important: When operating the detector, view the following security guidelines:

• Always switch on the gas supply before starting the power of the mobile phase.

• When you stop the gas stream, always switch off the mobile phase flow and let the detector remain pressure for 5 minutes before switching off the gas flow.

• Only switch on the gas stream when a nebulizer is installed.

• View the pressure surface of the gas supply (→ section 9, page 121) and the internal gas pressure setting as stated in the installation instructions for the nebulizer.

• Only work the detector when connected to the correct ventilation.Ventilation of exhaust gas must be with atmospheric pressure.

• If a leak occurs, switch off the detector immediately, stop the pump current and clarify the situation.

• If the pressure relief valve is open and wonderful gas, close the detector immediately.

• After the functioning of the detector, if you operate the detector with organic solvents in high concentration that peroxides can form due to evaporation (non-stabilized THF, 2-propanol, etc.), feel the power paths completely closed with HPLC degree water earlier.

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French security guidelines

Important: When driving and maintaining the detector, respect the following safety instructions:

• Always cut the gas supply before you start the power of the mobile phase.

• When you stop the gas stream, always switch off the moving phase flow and let the detector remain under pressure for your gas flow for 5 minutes.

• Only switch on the gas stream when a nebulizer is installed.

• Respect the gas supply area (→ section 9, page 121) and the adjustment of the internal gas pressure according to the confirmation instructions for the nebulizer.

• Only use the detector when connected to the correct ventilation.

• If a leak occurs, stop the instrument immediately, stop the pump current and dissolve the problem.

• If the discharge valve is open and flee out of gas, stop the detector immediately.

• After using the detector, if you use the detector with organic solvents in high concentration that peroxides can form during evaporation (non -stabilized THF, isopropanol), the current paths completely washed up with CLHP quality water before the detector is stopped.

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5.2 Teeth for the power to the detector

Before switching on the detector, you must ensure that all preparations for startup have been carried out (→ section 4, page 33).

To start the detector for the first time, switch the main switch on the rear panel of the detector.

The following order of events occurs when the detector is called in:

• Self -test diagnosis detector performs a number of internal tests.the heating screen.

• Heating phase in heating mode monitors the internal temperature of the detector.The heating time can be longer if the ambient temperature is cool or cold.

• Self -test error to fail in the self -test, write down the error code and contact Thermo Fisher Scientific Service for Dionex HPLC products.

For routine operation, the main switch is switched on.Switch off for the main switch when requested, for example before performing a maintenance procedure or when you disconnect the processing for long -term periods (a week or more).You also observe the precautions in section 5.8 (→ page 74).

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5.3 Operation of the detector from the touch screen

5.3.1 Overview

The display with the integrated touchscreen offers keys directly under the screen for checking and navigation.

The following table offers an overview and a short functional description of the available menus and screens:

See ... Until ... on page ...

Main menu - On/switch off the gas stream - Adjustment of care processing - advance to Run mode and system settings menus

Run -mode menu adjust parameters for test analysis 50

Diagnostics screen Monitor Internal Calibrate Parametre 51

Graph screen monitor and adjust the detector signal while collecting data

Evaporation temperature

Set the temperature of the evaporation tube 54

System settings Menu Edit Standard Parameters 55

Drainage -screen activates or switch off the drain pump -

Analog output screen

Install the analogue output -PC card in the detector company and adjust the signal settings

SSV screen reach the location of the power-changing valve

Gas regulator

Put and monitor internal background and print 56

Date and time setting screen

Set up the date and time and reset the following filter change and PM Data 57

Contacts and input screen

Enable output and monitor entry in 58

For all menus and screens, when a parameter is marked, this indicates that the user must select the softkey in the top right corner of the display to select the available settings.User Selectable Message.When selecting an item in the hooks, extra settings are available.

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5.3.2 Main menu

The main menu contains the serial number for the detector, the firmware version.

Fig.7: Main menu screen (here: Corona Veo RS)

Parameters description

The serial number indicates the serial number of your detector.

Firmware version indicates the installed firmware version.

The following options are available:

Soft key ... Choose ...

Light+ light

Adjust the brightness of the display, press Bright+ to increase, light to reduce the brightness of vision.

Gas on gas from

Switch on the gas stream to print the detector.If the internal gas stream is switched off, 'Gas at'. If internal gas stream is switched on, 'Gas off' is displayed as softkey.

System access to the screens used to select a number of general business parameters, such as defines default values, set time/date, etc. Page 55).

Performing mode starts an example analysis.For details, see section 5.3.3 (→ page 50).

Main menu

Serial number = 5081003

Choose the desired operation

Firmwareversion = 1.0

Gas on light+

System menu run mode

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5.3.3 ROUND AILENT MENU

In the main menu, press Soft Key Run mode to open the Run mode menu with the available functions and parameters.of the detector.

Fig.8: Run -Screen (here: Corona Veo RS)

If the gas is not yet switched on, the detector automatically starts the gas stream when you press softkey on the driving mode in the main menu.

The following functions and parameters are available in the menu.Choose the desired parameter and adjust if necessary.

Parameter Description Settings Standard setting

Currently detector signal while collecting data

Read only ---

Full scale percentage offset added to the analog output of the detector

-50 % to +50 % 0 %

Filter Digital Filter Constant used for output flow.

Filter time constants: 0.1, 0.2, 0.5, 1.0, 2.0, 3.6, 5.0, 10.0 seconds

5,0 Sek.

Power Function Data Lineering function 0.67 - 2.00 1.00

SSV position position for the power-changing valve

Dispatched, derivative atomizer

Area Set the signal current area of the analog output of the detector

1 Pa up to 500 Pa (in steps of 1, 2 and 5)

100 PA

Run State

Electricity = 0.000 PA full scale = -0 % filter (5.0 sec) power function (1.00) SSV position = spraying range (100 PA)

Auto Zero Diagnostics

Afwerking Graph evap t

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Corona VEO RS Only if the power change valve is not set to the nebulizer, the detector is automatically activated the valve.

The following action tests are available:

SoftKey Select for ...

Autozero adjust the output signal to zero in the current interval used.

Diagnosis opens the diagnostic screen (→ page 51).

Graph open the graph screen (→ page 53).

Evaporate the screen to open evaporation temperature (→ page 54).

To stop driving mode, print on Soft Key Soft key and on the next screen, press continuing softkey.

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5.3.3.1 Diagnostics screen

The diagnostic screen shows information with regard to factory sets and internal calibrated parameters.

Fig.9: Diagnostics -Screen (here: Corona Veo RS)

The following functions and parameters are available on the screen:

Parameters Description Typical values

Flowing circ*mstances indicate the ratio of the amplifier height bat and the background of load gaster in the factory calibrated.

Normal

Ionval removes very mobile Gzions.18 V - 20.9 V

Guest pressure indicates the inlet pressure of the gas source.276-448 KPA (40-65.0 psig ± 0.1 psig)

The evaporation temperature is displayed when the evaporation tube works and the actual evaporation temperature.

35 c

Loading voltage indicates the applied voltage to the Corona line to charge the (secondary) ionic current.

1.8 kV - 3.0 kV

Charging current indicates the power required to charge the (secondary) ionic current.

0,99 - 1,01 µA

To return to the Run mode menu, press the softkey settings.

Flow ratio = 0.42 ion trap = 20.5 V guest pressure = 62.9 PSI Evaporation temperature = on, 35 C charging voltage = 2.25 kV charger current = 0.99 µA

Exit Run mode Graphics

Auto null evap t

Diagnostics

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5.3.3.2 Gran Screen

The graph screen shows the online detector signal while collecting data.

Fig. 10: Great Screen (Hier: Crown I see RS)

The following functions and parameters are available on the screen:

SoftKey Select for ...

Get ± change the standard signal area.This function refers to the online plot series as shown.

Rate ± update the display speed.The price appears in seconds per second. Department.A speed of 4.7 indicates that every horizontal division is 4.7 seconds and the entire chromatogram is 47 seconds.

Car adjust the car -rate/gain.online plot setting automatically scales up the signal with the largest size of online plot.

Leave the exit from the graph screen.

Graf -display

Finish

Profit+

Run -modus Diags evap t

Power = 0.000 PA condition = normal reinforcement = 16 speed = 3.1

Special applicant+ rate car

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5.3.3.3.3 Damping temperature screen

The evaporation temperature screen sets the means to set and monitor the temperature of the evaporation pipe.

Fig.11: Damporation temperature screen (here: Corona Veo RS)

The following functions and parameters are available on the screen:

Parameters description

The temperature shows the actual evaporation temperature.

The current turns the temperature control of the evaporation pipe on and off.

SetPoint sets the measuring temperature of the evaporation pipe;The standard temperature is 35 ° C. Corona VEO: Two temperature settings are available: +100 ° C in phases of 0 steps, 1 ° C.

Tip: The actual temperature reached depends on various factors, including the composition of the mobile phases, liquid current speed, the temperature of the mobile phases, the guest temperature and the ambient temperature.

To ensure that the evaporation pipe comes to balance for the set temperature, you wait about 30 minutes after the temperature has changed before the sample analysis is started.

Evaporation temperature

Tempered: 35 c

Setpoint: (35) c

Switch)

Exit Run mode Graphics

Auto Zero Diagnostics

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5.3.4 System settings Menu

The system settings menu is used to edit a number of standard parameters with regard to the overall operation of the detector.

Fig.12: System settings Menu (here: Corona Veo RS)

The following parameters and functions are available in the menu:

SoftKey Select for ...

Date Set system date and time and also offer the possibility to reset the filter change and the following preventive maintenance date (PM).

Contact sets the situations of the digital output contact manually and activate the system response when a signal change is made to digital input contact.

Evaporate the screen to open evaporation temperature and set the evaporation temperature (→ page 54).

Empty or switch the drain pump.

Analog Install the analog output -PC card in the detection company.

SSV (when Corona VEO RS)

Use the SSV position status screen to get the location of the power-changing valve.

Gasset and check the inner gas pressure for the nebulizer (→ page 56).

To change one of the system meters of the detantor, select the desired softkey to view the function on the screen.The detector.

System Settings -menu

Select: To make changes, press Continue.Gastryk = 0.00 PSI

The main menu continues

Datum Contact evap t

Put analog SSV gas

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5.3.4.1 Gas regulator screen

The gas control screen offers the functions to set the gas pressure and press the device on the gas screen and to check the pressure.

Fig.13: Gas regulator screen (HAAR: CORONA VEO RS)

To set a pressure unit or internal gas pressure, select the desired softkey on the display.Available parameters or pressure values appear.Choose the desired parameter and press Save Soft Key to save your changes.

Gasregulator

Press = 0.05 bar

Setpoint (4.14 bar)

Printing units (beam)

System menu save the main menu

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5.3.4.2 Screen to date and time settings

Access to the date and time settings screen from the System Settings menu.The screen is used to set the current date and time.

Fig.14: Date and Time Setup screen (here: Corona Veo RS)

The following parameters and functions are available on the screen:

SoftKey Select for ...

Reset Filter CHG date shows the following date of replacement of the gas filter.If the date has expired, it will be indicated in red.

Reset Next PM date shows the following date of preventive maintenance.

Date and time settings

Month (June) Day (6) Year (2013)

AM/PM (AM) Time (9) Min. (42)

System menu save the main menu

Reset Filter CHG -SE Reset Volgende PM -Ded

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5.3.4.3 Screenshot -contacts and input

The contacts and the input screen are used to activate the individual outputs and to view the condition of the inputs related to the digital I/O terminals on the rear panel of the detector.

Fig.15: Contacts and inputs screen (here: Corona Veo RS)

The following parameters and functions are available on the screen:

Parameters description

Contact 1 and 2 before use with compatible chromatographic data systems to interact with external devices.

Pump dedicated output to connection with external pump.Under an alarm mode, a signal is sent to close the pump and stop the fluid flow to the detector.

Before use, start with compatible chromatographic data systems to start data collection.See the user documentation of the chromatographic software for more information.

Gas from dedicated input to close the gas flow to the detector.

Autozero adjusts the output signal zero in the current interval used.

SSV position for external regulation of the power change valve.

See section 11.1 (→ Page 129) for more information about digital input and output.

Main menu

Contacts and input

Kontakt 1 (off) contact 2 (off) pump (off) start = on gas off = on (active) autozero = on (active) SSV position = on (active)

System menu save the main menu

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5.4 Before carrying out the detector

5.4.1 Set the gas pressure

The internal gas regulations offers the gas pressure to the nebulizer to make aerosol.

Setting the gas pressure is required in the following cases:

• After you have installed or replaced the nebulizer.

• If the gas pressure has fallen outside the specified setting of the nebulizer.

• Corona VEO only the gas control button sometimes runs, so the gas pressure must be adjusted again.

• Corona VEO RS only if you operate the detector from a chromatographic data system and use the analytical or microlc gas flow mode.

The gas pressure must correspond to the recommended gas pressure setting as indicated on the certificate sent with the Focusjet -Vevevelaar.

Important: Always switch on the gas supply before starting the power of the mobile phase.

Important: Always cut the gas supply before you start the flow of the mobile phase.Up to a minimum of 5 minutes before switching on the power of the mobile phase.

Tip: If the gas pressure is used outside the recommended background pressure for the respective injector, the detector may experience a loss of performance.

Setting the stomach pressure for Corona VEO Set the gas pressure manually with the manual gas control button on the rear panel on the detector.138 KPA (20 PSI) per revolution.

Tip: note the gas pressure tax as indicated on the display before setting the gas pressure.

1. If applicable, stop the mobile phase current of the pump and wait a few minutes until the detective pressure stabilizes.

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2. If applicable, select the Run mode Soft Soft key menu to return to the main menu.

Tip: If you operate the detector from a chromatography data system, you may need to interrupt the detector in the system to gain access to the main menu.

3. Select Syste Menu Soft key in the main menu.

4. Select Softkey Gas to view the current gas pressure value.

5. Before adjusting the pressure, loosen the meeting meeting on the Gaasbreelaar button on the bag panel on the detector.

6. Adjust the Gastrail:

♦ Turn the control button slowly clockwise to increase the gas pressure.

♦ Turn the control button slowly against the clock to lower the gas pressure.

7. When you turn the button, monitor the climb or fall in the gas pressure on the detector screen.

8. Roof the regulation button again.

9. Wait until the gas pressure is stabilized and the set has reached.

The guest -Set pressure on Corona Veo RS

Regulate the inner gas pressure of the display to offer a consistent nebulizer pressure for a stable aerosol.

1. If applicable, stop the mobile phase current of the pump and wait a few minutes until the detective pressure stabilizes.

2. If applicable, select the Run mode Soft Soft key menu to return to the main menu.

Tip: If you operate the detector from a chromatography data system, you may need to interrupt the detector in the system to gain access to the main menu.

3. Select Syste Menu Soft key in the main menu.

4. Select Softkey Gas to view the current gas pressure value.

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5. Select SetPoint and set the pressure point to the desired value.

6. Select Soft Soft key and then leave Soft key to return to the main menu.

7. Wait until the gas pressure is stabilized and the setting point reaches.

Monitoring the guest -Scrue to check the guest -Scrue on the detector screen:

1. Select Soft Key Run mode in the main menu.

2. Select Diagnostics Soft Key in the Run mode menu.

3. On the diagnostic screenshot, monitor the reading of gas pressure.

5.4.2 Preparation of the system

Before using the detector, rinse the LC system thoroughly for the sample analysis.

1. Remove each analytical column from the system.

2. Rinse the system with a starting solution of 80 % water and 20 % methanol without the detector until the system is free from a different liquid composition.

Tip: When you use an online debris in your system, you must rinse any channel in online gas before using it for sample analysis with the detector.

3. Pre -programming all temperature -controlled devices, such as the pillar, for the required temperature for application.

4. Change the solvent to the mobile phase required for your application

5. Rinse the system without the detector with the mobile phase for your application until the system is free from the start resolution (80 % water/20 % methanol).

6. Reinstall the analytical column.

7. Rinse the system without the detector until the internal column volume is replaced by a new mobile phase.

8. Monitor the pump pressure.Controller that reading is correct for application and is stable.

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5.4.3 Bilibration of the detector

After you have prepared the system, you carry out a balance to the detector.

1. Start the gas supply.Complete the requirements for the gas supply in section 3.1 and guidelines for gas supply in section 4.5.3.

Important: To prevent damage to the detector, the maximum gas pressure of 550 kPa (80 psig) does not exceed the gas supply.Phase flow.Only turn on the gas stream when a nebulizer is installed

Important: Do not exceed a maximum gas pressure of 550 kPa (80 psig) for gas supply.

Always cut the gas supply before starting the power of the mobile phase.Up to a minimum of 5 minutes before you use the power of the mobile phase.

2. On the detector screen, select the softkey of the Softkey of the Run mode.

The gas stream starts automatically.Optionally you can determine the gas power before starting the acquisition in the main menu (→ page 49).

3. Determine the evaporation temperature on the Evaporizing temperature screen.

4. Start the delivery of the mobile phase.

View the guidelines for mobile phases and tracing specifications for the detector.

Tip: Make sure you save the flow rate within the specified interval for the detector (→ Page 121).

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The following table is to help you with typical flow rates of certain sloping diameters:

Diameter Diameter column

4,6 mm 1,0 ml/min

3,0 mm 0,5 ml/min

2,0 mm 0,2 ml/min

1,0 mm 0,05 ml/min

Fig.16: Typical flow rates for different columns

5. Have the Økvilibring detector until you perceive a stable basic line of the basic detector.

6. The detector is ready for data collection when the baseline is stable.

7. Autozero detector: Press the Run mode menu on soft key autozero.

8. The detector is now ready for sample analysis.

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5.5 Implementation of sample analysis

This section provides information for performing sample analysis with the detector.After you perform an analysis, you must set business parameters from the detector screen (→ section 5.3, page 48).

5.5.1 Start and Stop of collecting data

Make sure you have set the required parameters and that the system and the detector are renewed and you can accelerate and stop data collection and the progress with data collection has set up on the display.

See page 53 to check data collection on the detector screen.

To start data collection from the detector screen

1. Select Soft Key Run mode in the main menu.

2. Equilibrium detector as described in section 5.4.3 (→ Page 62).

3. To check the progress with data collection on the display, see the current parameter in the Run mode menu with the online data signal in real time (→ page 50).

4. To stop collecting data, press SoftKey Exit Soft key in the Run mode menu and select continue leaving.

5.5.2 Operation of current change valve (Corona VEO RS only)

The stream switch valve can be used to send power to the nebulizer or to distribute to external units or waste.

When the detector is controlled from chromatographic software, such as Chromeleon, the valve can be activated as part of the chromatographic method.So simplify the chromatogram.

Tip: If you operate the detector with another detector of chromatography software, the valve can distract the fluid flow to the other detector or liquid handling and/or collect.

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5.6 Optimization of the performance of the detector

The service of the detector can be optimized through a careful choice of important operating parameters.

Company Parameter Performance -Pers and Properties influence Selection Guidelines

Filter constant sensitivity, Basic noise see page 66

Baseline noise of evaporation temperature, background current see page 66

Gas stream modes see page 67

Linear range of the Linear Capacity Function, See Page 68

Baseline cross sensitivity, reproducibility see page 68

Resolution of data collection, disk space, possibly baseline noise see page 69

5.6.1 General guidelines

• Make sure that the HPLC column is stable (in power and temperature) and at PH in your mobile phase.

• If the mobile phase is stored for a certain period, a high background current can be observed.

• When using the detector to analyze complex biological samples, the right sample preparation is especially important.

• Rinse new analysis columns to waste a few hours before they connect with the system.Use a special column for each specific analysis to prevent cross -contamination of the column.

• To fully use the possibilities of power connections in a UHPLC system, especially when using columns with smaller inner diameters, minimize dead volumes before the detector.The shortest possible length.

Tip: When performing a gradient, it is recommended to perform empty injections with the desired LC-methodgradient profile before analysis.

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5.6.2 Setting a filter constant

The filter time constant is used to electronically reduce the noise of the basic line within chromatographic driving.

See section 5.3.3 (→ Page 50) For more information about setting the filter constant of the display.

5.6.3 Selection of the evaporation temperature

General remarks

The temperature -controlled evaporation pipe dries the aerosol from the nebulizer.Thus, the evaporation pipe removes the mobile phase components and leaves an aerosol with dried analytes.You have set the evaporation temperature, wait about 30 minutes to ensure that the evaporation pipe comes to balance before the sample analysis is started.

Tips: A change in the evaporation temperature can have a dramatic effect on the detector's response.

Corona VEO RS Only If you decide to use an optimized evaporation temperature, you must perform three or more injections of a reference standard for the analytical method.Suitable starting point temperature, based on the performance criteria as stated earlier.

See the table below for a starting point for selecting an evaporation temperature:

Factor evap

Effect corona I see crown I see rs

Composition of mobile phases

100 % watery 50 ° C

Use settings with a lower or higher temperature

Baseline noise, background stream

100 % organic (eg normal phase HPLC) 50 ° C

Water/acetonitrile or methanol gradient (eg inverted phase or Hilical HPLC)

35 ° C.

Water/THF -gradient 35 ° C Baseline Ruis

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Factor evap

Effect corona I see crown I see rs

Composition of mobile phases

Volatile modificators (eg TFA, formic acid, ammonium format)

35 ° C Eller 50 ° C

Non-fleeing modifications (with sodium phosphate) do not use ---

Mobile Phase Place Happense 35 ° C minimal

Analyst

Non-fleeing 50 ° C 35 ° C or 50 ° C minimal

Semi-filly factory settings of 35 ° C for lower or higher temperature

Detection response, basic noise

5.6.4 Use gas flow states (Corona VEO RS only)

The Corona VEO RS detector is capable of two separate gas pressure states: analytical gas stream mode and microlc gas flow mode.

Each of these modes sets a specific pressure based on the standard gum pressure for the nebulizer.They are designed as a simple way to optimize the efficiency of the atomizer when using ML/min - 2.00 ml/min.

• Analytic gas flow status: The sentence point of the gas pressure corresponds to the standard gas pressure setting as described in the certificate sent with the nebulizer.

• Microlc gas flow mode: The gas pressure value is calculated by multiplying the analytical gas stream mode by a factor to optimize the gas pressure for certain types of liquid current speeds and mobile phase assemblies.

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5.6.5 Application of a power function value

The signal from the detector has a wide dynamic range with more than four size orders.Linear interval.has been scaled and sent.

The choice of an optimal power function value will result in an increase in the linear dynamic range for the detector compared to the standard setting.

Tips: Changes in PFV do not lead to improvements in the limit of the detector for detection (LOD).

The standard PFV setting of 1.0 offers a good universal setting for most applications and connections.

The detector accepts each value between 0.67 and 2.00 in steps of 0.01.

To set the power function value of the detector display:

1. On the detector screen, select the main menu in the Run mode Soft key menu.

2. Set control parameters as required in your application.

3. For the Power function parameter, enter the three digits in the desired PFV without a decimal point.

4. Press Enter.databrømen is now being raised to the selected current.

5.6.6 Minimalization of baseline -inise

Minimalization of baseline judge generated for a certain LC method depends on many factors.

• Only use mobile phases of the highest available quality and keep impurities and pollutants to a minimum.

• Rinse the LC system periodically to remove non-volatile mobile phase residues if applicable.

• View the recommended maintenance plan for the detector and the LC system in accordance with the manufacturer's guidelines.

• The gas supply must be filtered and free of moisture and hydrocarbons.

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5.6.7 Guidelines for collecting digital data

When you operate the detector from a chromatographic data system, you can select the digital data collection speed to optimize the outlet of the detector. Second (HZ) that collects chromatographic software from the detector and stores as unprocessed data.

Note the following guidelines:

• Define each top with at least 20 data points.

• If all tops are relatively wide, select a lower speed of data collection (for example 1.0 Hz).

• If there are smaller tops, are less than a few seconds, select a higher speed of data collection (for example 20.0 Hz).Treatment time.

Tip: If you use the Chromeleon chromatography data system, data can be generated with Corona VEO with a maximum gathering speed of 100 Hz.In Chromeleon 7.

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5.7 Internal security functions

5.7.1 Department of Medicine

When a leak is derived from the capillary connections with the nebulizer or power valve (Corona VEO RS) and the leak sensor reports a leak, a warning code is displayed on the detector screen.

When the Lekmut reports a leak, remove the cause of leakage and dry the leak (→ page 112).

Tip: If you operate the detector from a chromatographic data system, a warning code is also documented in the Audit Tracks of the software.

5.7.2 Internal floating detection

A liquid sensor is installed in the detector to detect excess liquid structure in the case of a flood in the detector.

When excess fluid is present in the detector;

• A critical error code appears on the detector display.

• The detector is completed the rice status.

• If the pump of the relay is connected, the pump stops the power of the mobile phase.

• Corona VEO RS: The power switch valve will activate and distract the liquid current van der Detector.

• The rotation pump is switched on automatically.

Tip: If you serve the detector of a Chromatography Data System, an error message is also documented in the Software Audit Tracks.

If the sensor reports surplus liquid in the interior of the detector, stop the mobile phase, if not done and let the gas stream be switched on..

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5.7.3 Valve for relief valve for gas supply

A pressure relief valve is installed in the inlet of the gas supply to prevent damage to the detector in the case of an overpressure of gas.Sound.If the detector is in the Run mode, the detector is not pressed and an error code appears on the detector display.

Warning: if the pressure relief valve leaks during the operation or releases gas.

Warning: If the discharge valve is a leak during the operation where the release of gases, stop the detector

Close the detector.

immediately

To remedy the situation:

1. Switch off the gas stream.

2. Clean the error code on the detector screen and return to the main menu.

3. Close the gas supply to the detector.

4. Check the gas pressure supplied on the detector screen.Only the gas pressure so that the pressure of the input gas supply is in the range of 480 - 550 kPa (70 - 80 psig).

5. Switch on the gas supply.

6. If the gas pressure has fallen within the specified interval, the relief valve for the gas pressure remains closed.

7. Select Gas Soft key in the main menu to press the detector.

8. Select Syste Key system menu in the main menu.

9. In the System Settings menu, select Gas Soft Key to view the current gas pressure value of the gas regulator.

10. Make sure the gas pressure has returned to the standard setting.

11. Return to the main menu on the display.

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5.7.4 Alarm for FlowForhold

The detector continuously monitors internal pressure.On the Diagnostics screen, the power ratio offers diagnostically detailed pressure information for internal components.

• An error code appears on the detector display.

• The detector is completed the rice status.

• If the pump of the relay is connected, the pump stops the power of the mobile phase.

• Corona VEO RS: The power switch valve will activate and distract the liquid current van der Detector.

• The rotation pump is switched on automatically.

Tip: When you operate the detector from a Chromatography Data System, an error message is also documented in the Software Audit Tracks.

See the 'Solve problems' section (→ Section 7, page 91) For more information about resolving an alarm status of a power ratio.

5.7.5 Detector overstromingsalarm

If the detector is correctly connected to a pump in a LC system as described in section 3.4.4 (→ page 31), the system can receive a contact closure from the detector in the case of a critical error.

Tip: Most LC pumps are programmed to send a general contact closure in the case of a low pump traction alarm as determined in the configuration.

When the gas pressure falls outside the specified range of 241 - 480 KPA (35 - 70 PSI), the following actions will occur:

• An error code appears on the detector display.

• The detector is completed the rice status.

• If the pump of the relay is connected, the pump stops the power of the mobile phase.

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• Corona VEO RS: The power switch valve will activate and distract the liquid current van der Detector.

• The rotation pump is switched on automatically.

Tip: When you operate the detector from a Chromatography Data System, an error message is also documented in the Software Audit Tracks.

To solve the problem:

• Check the gas supply for leaks (if applicable) and ensure that the gas supply is connected correctly.

• Set the gas pressure to the setting specified for your injector (→ page 59).

• Reset the pump and restart the analysis.

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5.8 Closure of the detector

5.8.1 Short -term shutdown

If the detector is not used for a few days, the detector will remain connected to the system and the detector and the system will be switched on..

• Keep the detector connected to the system current.

• Keep the detector connected to the Chromatographic Data System if applicable.

• Switch off the mobile phase current.

• If there is enough gas supply available, you will continue to flow through the detector with a low gas flow.

5.8.2 Long -term closure

If the detector is not used or sent for a longer period, take the following steps before you interrupt the operation:

1. Rinse all the solvents of the detector.Rinse the detector with a neutral solvent that contains no salts.All buffers, sour modifications, etc. of the detector cannot be exposed to long periods of too much acid or basic mobile phases.

2. Switch off the mobile phase current.

3. Allow gas to flow for at least 5 minutes.

4. Switch off the gas stream.

5. Wait a few minutes until the detector can be pressed.

6. Switch off the gas supply to the detector.

7. Press the power switch on the rear panel detector to switch off the detector.

8. Disconnect the gas pipes from the rear panel of the detector.

9. Disconnect the power cord from the main power vessel and all other cables and capillaries of the detector.

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10. If you prepare the detector for shipping

a) Remove the injector of the detector as described in paragraph 8.6 (→ page 115) .b) Save and send the injector in its original shipping box.

Shipping of the detector Use the original shipping container and observe the packaging instructions.Organization for Dionex HPLC products.Is included in the binding agent "Installation and qualification documents for Chromatographic Instrument" and are also available on request.

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6 The Chromeleon software detector can be checked by Chromeleon Chromatography Management Service Release 13 or higher.

TIP: All software information in this section refers to Chromeleon 6.80. If you want to serve the Chromeleon 7 detector, consult the following documents for information about performing the related processes in Chromeleon 7 (all documents are included in Chromeleon 7 Send):

• Chromeleon 7 Help - offers extensive information and extensive reference material for all aspects of the software.

• Fast start guide describes the most important elements of the user interface and guides you step by step through the most important workflows.

• Reference map - offers a brief overview of the most important workflows.

• Installation - instructions - provides basic information about the installation and configuration of module.

Also note the following:

• Chromeleon 7 -terminology differs from the terminology used in Chromeleon 6.80.See 'Glossary -Chromeleon 7.0', which is available in the documents of your Chromeleon 7 installation.

• Chromeleon 7 may not support all functions that are supported in Chromeleon 6.80.

Two forms of software control are available:

• Direct control of direct controls, select control parameters and assignments in the Commando (F8) dialog box.More information about direct control, see page 86.

• Automated control of automated controls, make a program (or PGM file).Existing program.See page 88 for more information about automatic control.

See Chromeleon Help for information about the available functions and parameters of the Chromeleon detector.

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6.1 Set up the detector in Chromeleon

This section contains short instructions for setting Chromeleon.See also Chromeleon -Help for details.

Tip: when the detector is connected to the Chromeleon computer, check that the Chromeleon software is installed before you first switch on the detector capacity.When the force is switched on.

6.1.1 Loading the USB controller to the detector

1. Switch on the computing power if it has not yet been switched on.

2. Under Windows Vista® (Windows® XP, Windows® 7 or Windows® Server 2008) Log in if a • Local manager if the computer is a local computer • User with local computer administrative rights if the computer is a network

computer.

3. Open the Chromeleon Server Monitor program by double-clicking Chromeleon

SERMONIGONOR ICTAGRAGE ON THE WINDOWS PROCCOCTION LIVE.

If the server monitor icon is not on the taskbar, click Start on the taskbar, point to programs (or all programs, depending on the operating system), point to Chromeleon and then click on Server Monitor.

4. Click Start to start the server.

5. Click Close to close the Server Monitor window.Server Monitor icon appears on the taskbar.

Tip: Click on the Serge Monitor Program of the Exitmonitor (Output), but does not stop the server to stop the server.

6. Switch on the main switch on the rear panel of the detector.

7. Windows Vista, Windows 7 and Windows Server 2008 automatically detects the new detector and performs the USB installation.

If Windows does not detect the detector and starts a guide instead, this indicates that you have connected the detector to the computer and switched on the power for the first time before installing Chromeleon.

a) Click Cancel to leave the wizard.

b) Switch off the detector.

c) Installer Chromeleon.

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d) Switch on the detector power.Windows now detects the detector and automatically installs the USB software on the detector.

Windows XP automatically detects the new detector and starts the found new hardware guide that you lead through the USB installation.

a) If Windows can connect to Windows Update to search for software, don't choose, not this time.

b) Accept the standard setting (install the software automatically) and click Next>.

c) Click Complete when the Wizard reports that the software for the detector is installed.

If Windows XP does not detect the detector and a message box requires a USB configuration file (cmwdmusb.inf), this indicates that you have connected the detector to the computer and first switched on the power before installing Chromeleon.problem:

a) Click Cancel in the Windows message field.

b) Switch off the detector.

c) Installer Chromeleon.

d) Switch on the detector power.

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6.1.2 Installation of the detector

The detector must complete the self -test before the detector is connected to the computer to prevent possible installation errors.When the display shows the main menu, the Self -Test is complete and the detector is ready for connection.

When the USB software is installed to the detector (→ page 78), install and configure the detector in Chromeleon:

1. Start Chromeleon Server Monitor (→ Page 78) and the Chromeleon server if they are not yet performed.

2. Start the Chromeleon Server configuration program by clicking on programs (or all programs, depending on the operating system) on the start of taskbar.

3. If necessary, click on the plus sign next to the server icon to view the items below.

4. Select the time base assigned to the detector or create a new time base (click on Timebase in the Edit menu).

5. Open the Time base dialog box.To do this, click Add the Device menu in the edit or right -click on the time base and click on adding device in the menu.

6. Click on Corona Veo, which is charged on the list of producers.

7. Open the configuration pages.Controllers on each page are the settings correct and, if necessary, select Extra Settings.

8. Click OK to complete the detector's configuration.

9. In the File menu, click Save installation and then close the server configuration program.

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6.1.3 Configuration of the detector

6.1.3.1 First installation

During the installation, Chromeleon creates a connection with the detector and transfers the settings of the instrument to Chromeleon, which sets the settings on the pages accordingly.To change the settings (→ page 84).

TIP: Changing the settings for a specific application in the Assignments dialog box (F8), in a program file (PGM) or on a configuration screen, the standard settings on the configuration pages do not change.

Click on Help for more information about a page.

General side shows the general detector parameters.

Fig.17: General page

• Virtual mode check whether the virtual mode is set.If the virtual mode is switched on, the Module address field is not available.

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In the virtual condition, Chromeleon simulates detector control and data collection.

♦ Click Read and display data from an existing demo file instead of real data.

♦ Click Write to save the data that is currently supplied by the detector as a demo file.Intast the file name in the Virtual Modus File name field or select a name from the list.

• Module address, if necessary, select the module address of the detector.Automatically entered in the Module address field.

• Download click on this button to transfer the current firmware version to the detector.(The button seems filled when the virtual mode is switched on.) The detector is sent with the latest firmware version.8.9 (→ Page 119).

Detector page shows the detector configuration.

Fig.18: Detectorpagina

• Detector type Select the detective type.In order of the selected option to match the actually installed detective type.

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• Device name shows the name to identify the detector's installation environment and in the Chromeleon client program.Panels and edit the device name in the program files.

Signal page shows all signal channels that Chromeleon can register for the detector.Signal.Change the signal name, overwrite the existing name directly in the name members.

If the signals are renamed during the configuration, it is also necessary to update the set of the panel coil.

Fig.19: Signals page (here: Corona Veo RS)

Relay side relays page with all available relay.The reference to relay exits CC1 and CC2 on the rear panel of the detector.

The output 'Pump OFF' is not available in Chromeleon.

Select a check box to control the relay of the detector loss to control the detector loss panel in Chromeleon.the existing name directly in the corresponding rule.

Fig.20: Reisisijde

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6.1.3.2 Change the configuration -properties You can reopen the configuration pages later to change the settings.

1. Start ServerKonFigationsProgrammet (→ Side 80).

2. Right-click the Corona Veo-Charged aerosol detector in the time base and click on properties in the menu.

3. Change the settings if necessary.For a description of the pages, see section 6.1.3.1 (→ Page 81).

4. To save the changed configuration, click Save in the File menu and then close the server configuration program.

6.2 Setting the detector in DCMlink

Consult the DCMlink installation guide to configure the detector in DCMlink, which is supplied on the DCMlink -DVD in the further documents \ DCMlink user documents.

1. Install and configure the DCMLink software (→ DCMlink -installation -instructions).

2. Open the Chromeleon Server configuration program (→ DCMlink installation -instructions).

3. Add the detector to the time base in the server configuration program.Follow the relevant steps in section 6.1.2 (→ page 80).

4. Configure the detector as described in paragraph 6.1.3 (→ page 81).

See DCMlink Quick Start Guide for more information about DCMlink, which is also supplied on DCMlink DVD and for DCMlink -Help.

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6.3 Operation of the Chromeleon detector

Check that before you start

1. The Chromeleon software is installed on the computer and the license code is entered.D.Computer meets the system requirements (→ page 11).

2. The detector is connected to the Chromeleon computer via a USB connection.

Tip: Make sure the Chromeleon is installed on the computer and that the license code is entered before the detector is connected to the USB port of the Chromeleon computer and first deploy the detector capacity.Windows operating system can detect when the power is switched on.

3. The detector is set in Chromeleon, as described in paragraph 6.1 (→ Page 78).

Before you can operate the detector from Chromeleon, you must connect the time base where the detector is installed on the Chromeleon client program (→ page 85).To form software controls are available:

• Direct control of parameters and assignments from the Assignments dialog (F8) (→ Page 86) or a control panel (→ page 87).

• Automated control of a control program (PGM) (→ Page 88).

6.3.1 Connection to Chromeleon

1. Start Chromeleon Server Monitor and the Chromeleon Server if they are not yet performed (→ Page 78).

2. Start the Chromeleon client by clicking on the Chromeleon icon on the desktop.If the Chromeleon icon is not on the desktop, click Start on the taskbar, point to programs (or all programs, depending on the operating system), point to Chromeleon and then click Chromeleon.

3. Connect the Chromeleon client program to the time base where the detector is installed.87.

Before switching off the detector at the main switch, always interrupt the detector in Chromeleon.

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6.3.2 Direct control

With direct controls you select business parameters and assignments in the Assignments dialog box (F8).

To open the assignment dialog for the detector 1. Open a control panel (each panel is possible).

Chromeleon-Browser and double-click a control panel in the Dionex templates/panels folder.

2. Connect the control panel to the time base where the detector is installed.Select in the control menu, select Connect with Timebase and then select Timebase on the Timebase tab (the Control menu is only visible when a control panel is opened. Information about the Time Basis dialog box, you must click on Help.

3. Press the F8 key or select the order in the Control menu.

4. Click on the plus sign next to CAD to view the parameters and assignments that are available for the detector.

The assignments and parameters that are available in the dialog box vary depending on ♦ Chromeleon version ♦ Settings selected for the detector in the Properties dialog box (→ page 81).

5. Change the filter level of the display if necessary.

Fig.21: dialog assignments

6. Make sure the detector is connected to Chromeleon.If this is not the case, choose to connect to the detector.

See Chromeleon -Help.Sfosfund Detector assignments and parameters for a list of assignments and properties supported for the detector, assignments (F8) access to all assignments and parameters available for all devices installed in the selected devices.

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To open a control panel 1. Click on the standard panel loss or click on the corresponding icon

Toolbar, and then connect to the Chromeleon server.Chromeleon creates centralized control panels, called paneling, for all available time races on the Chromeleon server.More panels to perform systems, such as creating and performing sequences.

2. Click on the Down Panel page for your time base for the detector.

3. Make sure that the detector is connected to Chromeleon (the connecting button is green).

Fig.22: Detectorcontrolepaneel

The control panel offers access to the business parameters and the assignments that are required for a routine operation of the detector.In the menu control.

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6.3.3 Automated service

With automated control you can create a program file (PGM) for automated operation of the detector.

In addition to programs for example analysis, you can also create programs for special purposes, for example to automate system closure (→ page 111) or to ensure that the system automatically starts operation again based on a power switch.staff.

You can create a program:

• manually (→ see below).

• With the program of the program (→ page 89).See page 89 for information, how to start a program.

To make a program manually 1. Open an existing program.

Select and Double on the program that you want to open. - Select Open in the File menu.In the dialog box, select the program on the typing list object and select the program.

Fig.23: Chromeleon -Program -file (here program shown in the assignment view

For Corona Veo RS)

Open the device views

Opens the assignments

Display

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2. Change the settings in the program as desired.

The easiest way to edit a program is to do this in the device views (→ Fig. 23).Click on a device icon and change the settings on the devices.

If you are unable to edit a specific parameter in the display of the device, click assignments to open assignments.Command display shows the entire program that reflects control assignments in chronological order.

3. Follow the steps below to start the program.

To make a program with the program guide 1. Open the program guide.Select news in the filmmenu and then select the program

Fil.

2. The guide leads you by making the program.

3. When you complete the guide, Chromeleon automatically makes the corresponding program.

4. Follow the steps below to start the program.

To start a program program for sample analysis 1. Make a test list (order).

For evaluating the sample data (for example for top identification, determination of the area and the quantity amount).

2. Assign the program and the method to each test on the list.

3. Add the series to the batch and start the batch.

See Chromeleon Help for information about each of the above steps.

Other programs add the program to the batch and start the batch.

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7 Solving problems

7.1 Overview

The following functions help you identify and eliminate problems that can occur during the operation of the detector or the system.

• Status screen On the detector display on the front panel offers rapid visual control over the operational status of the detector.

• Solving problems Checking to insulate the cause of a problem (→ page 92).

• Self-test diagnostics and error codes If errors are detected under the self-diagnosis of power-up, an error code is displayed on the detector display.'(→ Section 7.2, page 93).

• Error and warning codes If an error or error is detected during the operation of the detector, a code is displayed in the detector display.If you serve the detector from a chromatographic data system, a message is also documented in the Software Audit Stracks.

• Business problems for information about business problems that can occur during the operation of an ultimate 3000 system, see the 'business problems' section (→ section 7.4, page 99).

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Fast problem solving scheme

The following guidelines can be used to quickly insulate the cause of a problem.

1. Enable the detector and wait for the result of the self -test.If the test fails, you must notice the error code and check the 'Self -test error codes' section (→ Section 7.2, page 93).

2. If the detector is not switched on:

a) Check the power cord and make sure it is connected correctly.

b) Check the fuses on the rear panel of the detector.

3. Check it

♦ All gas connections are made correct, there is no signs of leakage and the gas flows.

♦ The external gas supply pressure is 480 - 550 kPa (70 and 80 psig).

♦ The exhaust hose on the back of the detector is free of nodding, blockages or loops and that ventilation is free of blockages.

♦ All connections in the LC system stream path, including the detector, are correct and that there are no visible signs of leakage.

♦ The gas filter unit (located in the interior on the right side of the detector) is correctly confirmed.

♦ The other system components are connected and work correctly according to the instructions for each system components.

♦ All synchronizing digital I/O connections are made and work correctly.

4. Make sure that recent maintenance procedures have been carried out correctly as described in section 8.3 (→ page 109).

If you are unable to solve a problem according to the instructions given here, contact Thermo Fisher Scientific Service for Dionex HPLC products.

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7.2 Self -test FEJL -Codes

Internal self -test diagnostics is performed when the detector is switched on.If the diagnosis determined that there is an internal problem, the detector is not ready for analysis and an error code is displayed on the display.

If the self -test fails during startup, the detector shows a sum of the affected self -test error codes.

1. Select SoftKey for review.The first message for self -test review appears on the screen.

2. Select the test name in brackets to view the results of the E -mail.Naviger via the self -review with the next and last soft keys.

3. Note a failed self -test and their respective values for your items.

4. Select Continue SoftKey to complete the self -review at any time.

Tip: Selecting continuous softkey at any time during the self -review will bypass the results and by standard to the main menu.

If an error code appears on the display, switch off the detector, wait a few minutes and turn on the detector to repeat themselves -diagnostics.On the detector, error code or the exact formulation of the message and the available firmware number number.

Error code description

1 The detector did not reach the maximum voltage.

2 An error occurred with the high voltage output when the Corona charger voltage was switched off.

4 An error has occurred with the high voltage flow at maximum voltage.

8 An error occurred at the charger current when the Corona Charger voltage was switched off.

10 An error occurred when reading the transducer of the electricity ratio at the zero pressure

20 An error occurred when reading the print transucer with zero edition.

40 An error occurred when reading the total power trans then with zero pressure.

80 An error occurred with the ion catch that is at startup.the detector for 24 hours.

100 An error has occurred with the ion catches when the ion catch voltage was switched off.Or blockages.Only the gas through the detector within 24 hours.

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Error code description

200 The detector has not reached an internal temperature of a smooth condition.

The 400 watch is not set.

800 clock is not running.

1000 Urbatter is low.

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7.3 Warning and error codes

Every time there is an error or error during the operation of the detector, a warning code or error code appears on the detector screen.In this case, the submitted test appears on the navigation display

If you serve the detector from a chromatographic data system, a message is also documented in the Software Audit Stracks.

Warning codes The following table shows detector related warning codes and messages, together with recommended remedy promotions.

Note the warning code or the exact formulation of the message and contact Thermo Fisher Scientific Service for Dionex HPLC products if you cannot solve the problem.

Warning code Warning Description and Cure

15000 charger voltage has failed

The voltage of the charger is approaching the maximum level.

15010 Leksensordefects detected

The Lek has reported on a leak.

15008 Stream-Switching Valve (SSV) FEJL

Corona Veo RS Only SSV did not play., replace the rotor and stator (→ section 8.7, page 116).

15011 High engine temperature

The internal temperature of the detector is too high.

15012 Low engine temperature

The internal temperature of the detector is too low.

15013 High evaporation temperature

The temperature of the evaporation pipe is too high.Set a lower temperature in the specified interval (→ section 5.6.3, page 66).

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Warning code Warning Description and Cure

15014 evaporation error

The evaporation heating did not use the chosen temperature.

Error codes The following table shows detective -related error codes and messages, together with recommended remedy promotions.Error codes immediately result in the discontinuation of data collection from the detector and ends all automatic sequences or batchruns when operating the detector of a chromatographic data system.

If not seen, error codes can lead to permanent physical damage to the detector.

Note the error code or the exact formulation of the message and contact Thermo Fisher Scientific Service for Dionex HPLC products if you cannot solve the problem.

Error code error message description and remedy

29006 Low gas pressure The gas pressure has fallen under 241 kpa (35 psig).

The contact closure was sent to the digital I/O terminal of the detector.If a pump is connected to the digital I/O, the pump current is stopped on the detector screen.Power -changing valve will distract liquid flow from the injector to prevent flooding of the detector.

Ensure that • The pressure of the gas supply is in the range of 480 kpa - 550 kpa

(70 - 80 psig) and that gas is still delivered to the detector.

• Reading the background pressure on the detector screen is the area 276 KPA - 448 KPA (40 - 65 psig).

• gas supply tubes are correctly installed at the back of the detector and that there is no evidence of a gas leak.

• Gas filters are installed correctly and that there is no sign of gas leakage.

Switch off the detector and switch off the self -test the pressure sensors.

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Error code error message description and remedy

29004 High gas pressure The gas pressure has risen above 448 KPA (65 psig).Pump is connected to the digital I/ O, the pump current is stopped.from detector.

Ensure that • The pressure of the gas supply is in the range of 480 kpa - 550 kpa

(70 - 80 psig) and that gas is still delivered to the detector.

• Guest pressure On the detector screen, the range is 379 KPA - 448 KPA (55 - 65 psig).

• Gast supply tubes are correctly installed at the back of the detector.

• Gas filters are installed correctly.

The pressure relief valve opens when the pressure of the gas supply is greater than 550 kPa (80 psig)...

29002 Low power conditions The gas flow ratio (gas pressure charge gas) is more than 60 seconds outside the specification., the pump current is stopped.

• Gasto suppression is in the range of 480 KPA - 550 kPa (70 - 80 psig) and that gas is still delivered to the detector.

• Guest pressure On the detector screen, the range is 379 KPA - 448 KPA (55 - 65 psig).

Switch off the detector and turn it on and let the self -test test the pressure sensors.If the error continues to exist, there may be an internal leak or possibly gas block due to internal fluid floods in the detector.

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Error code error message description and remedy

29003 High power ratio The gas current ratio is outside the specification for more than 60 seconds.stopped.

• Gasto suppression is in the range of 480 KPA - 550 kPa (70 - 80 psig) and that gas is still delivered to the detector.

• Guest pressure On the detector screen, the range is 379 KPA - 448 KPA (55 - 65 psig).

Turn off the detector and turn it on and let the self -test test the pressure sensors.If the error continues to exist, there may be a possible gas block within the detector.

29009 Liquid sensor error detected

Liquid is present the blend room of the detector (→ fig. 29)., press every soft touch to continue.The pressure sensors.In the main menu, set the gas pressure and try to dry the liquid, there is 24 hours in the detector.

29,000 location ion valuation

Ion staircase is too low.Connected to the digital I/O, the pump current is stopped on the detector screen.Press every softkey to continue.Swallow to the detector and turn it on and let it test the pressure sensors yourself.In the main menu you can set the gas pressure and try to dry the liquid in the detector for 24 hours..

See section 5.7 (→ page 70) For more information about the internal security functions of the detector.

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7.4 Business problems

The following table contains information about common business problems that can arise with an ultimate 3000 system and mentions probable causes, as well as remedy actions.

Problem Truck Reason Remedy Actions

No information appears on the detector screen.

The detector is not connected to the main food.

Connect the power cord.

The power is switched off.

The brightness of the screen is not adjusted correctly.

Adjust the brightness (→ page 49).

The fuses are blown up.

An error occurred with the electronics.

Contact service.

Problems under control during Chromeleon

There is no connection between the detector and the Chromeleon computer.

Check the USB cable and connection with the computer.

The USB port on the computer is not ready for use.

Check the USB port on the computer.

The Chromeleon PC is very slow.

No liquid flow system delicious.

There is a gas bubble in the Autosampler -Flow Trail.

Perform a wash cycle (→ autosampler manual).No decorated washing solution is used.

For further reasons, consult instructions on your pump.

The system has a very high rear pressure.

Power gate components in the system (capillaries, filter and column) are blocked by precipitation or capillaries damaged by bending.

Check the capillaries in the system step by step from the detector to the pump, unblock or replace the capillaries.

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Problem Truck Reason Remedy Actions

The system has a very high rear pressure (continued)

Particles from the mobile phase, column or injected samples have been collected.

Make sure that the mobile phase and/or samples are sufficiently filtered before use (for example with an in-line filter).→ Page 41).Use freshly prepared mobile phase.

The solubility of the analyt (standard or sample) in the mobile phase exceeded.

Start the autosampler and isolate the pressure point to the detector.Explain in-line filter elements.

Nebulizer -nazles in the detector is hidden.

Poor solubility of analytes while building atomizing/analyte.Liquid must leave the capillary in drops.

Rinse the detector with a suitable composition from mobile phases to Solube analysis of the structure.

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Problem Truck Reason Remedy Actions

High basic line -Drift column is contaminated.

The system has not been sufficiently renewed.

Rinse the system into exprobation.

The eluents are dirty or not hom*ogeneous.

Before starting an analysis, hom*ogenizing is eluents who are already in their reservoir.

The environmental conditions are unstable.

Make sure that the temperature and humidity are constant.

The mobile phase is polluted.

Use verse solvent.

High noise, non-periodic baseline oscillation

There are pressure fluctuations of the pump.

Clean the pump;Check the general function (→ pump handbook).

There are air bubbles in the system.

Clean the system (→ pump manual).

Elent is dirty or their purity is insufficient.

Use verse solvent.

The gas content of the eluent is too high.

Degas eluenten.

The system is not grounded.

The mobile phase is polluted.

Use verse solvent.

Connections in the system delicious.

Check the leak system and, if necessary, tighten all suitable connections.

The mobile phase is not well mixed.

Check the blend function of the pump (→ pump manual).

Pollutants elusive from the column.

Spower levels of organic compounds can be closely remembered by the column.

Set The temperature is not kept constant.

Check the column space of the thermostats (→ TTC manual).

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Problem Truck Reason Remedy Actions

High noise, non-periodic baseline oscillation (continued)

There are temperature fluctuations in the laboratory.

Check the thermostat in the laboratory.Note if possible the temperature fluctuations/values in the system log.

Periodic baseline -swing, pulsation

There are pressure fluctuations of the pump.

Clean the pump;Check the general function (→ pump handbook).

There are air bubbles in the system.

Clean the system (→ pump manual).

Peak tail for large extra column volume Use short capillary connections with a suitable inner diameter.

There are bad capillary connections.

Use different capillaries, such as capillaries from Viper.

Height -extension, raised death time

The inner diameter from the capillary to the detector is too large.

Change capillary.

The filter fries on the solvent lines are hidden.

Check the filter for permeability.

The capillaries are hidden or capillary connections poor.

Replace the capillaries.

The monster eye is hidden.

The proportional valve is defective.

Contact service.

The column is overloaded or contaminated.

Cleans or replaces the column.

The eluent has changed.

Reproducible ghost stopper in the Chromatogram.

The degass channels are infected.

Rinse the descending channels (→ Solvent stands or pumping manual).

The solvents are broken down or dirty, or their purity is insufficient.

Use fresh and suitable solvents.

Pollution occurs in the autosampler or somewhere in the system.

Rinse autosamper or the entire system using a suitable solvent.

Some wide ghost peaks in the chromatogram.

Late supervision of earlier analysis.

Expand the driving time.

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Problem Truck Reason Remedy Actions

Peaks electric interference from other modules.

Isol the electrical circuit of strong power consumers.Before using an ups (uninterrupted power supply) to filter current fluctuations.

The pillar temperature is considerably above the boiling point in the mobile phase.

Use a cooler after the column or lower the column temperature.

Negative tops of sample solution and mobile phase are different in composition.

Solve the sample in the mobile phase.

Incorrect polarization of the analog output interface.

Check the analog output polarization.

Loss of response analysis of interest is not sufficiently stable.

Some connections are broken down as a function of time.

PH has been changed in the solvent or composition of the mobile phases.

Check the mobile phase.Mobil phases must be prepared fresh.

A parameter has been changed by accident.

Check the settings and check whether the detector has been switched on and the data collection has started.

Autosampler components can be partially or completely hidden.

Make sure that the sample and the mobile phase are pure.

The Stream-Switching Klep (SSV) is in a diversion position (only Corona VEO RS).

Make sure that SSV focuses fluid to the nebulizer.

The drainage pump of the detector has failed.

Make sure the drain pump is enabled in the System Settings menu.

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Problem Truck Reason Remedy Actions

Loss of response (continued)

Retention times changed.Make the column at a constant temperature.

Air is present in the pump or an incorrect flow rate is set.

The gas stream is switched off.

The gas stream is reduced.

Gas Delicious.

Liquid leaks during the detector inlet.

Check capillary connections.

Poor peak surface precision autosampler removes air from the vial.

There is insufficient amount of sample in the vial, setting the needle height is incorrect (→ autosampler -manual), or there are too many replicates.

There are air bubbles in the parts of the spray or autosampler connection.

Rinse the syringe (→ autosampler -manual).Non -depicted washing solution used.Gas washing solution (→ autosamper manual).

There is a gas bubble in the Stroompad.

Perform a wash cycle (→ autosampler manual).

Ticking speed is too high.Reducer pulling speed (→ autosampler manual).

The gas content of the sample is too high or saturated.

Reduce the draw speed (→ autosampler manual).Dega's sample if possible.

The needle is clogged whether the needle herb is distorted.

Replace the needle (→ autosampler -manual).

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Problem Truck Reason Remedy Actions

Bad Peak Area Precision (vervolg)

The autosamper, the injection valve or the spray valve is not tight.

→ AutoSampler Manual

Transfers occur in the system.

The capillary connections are not correctly installed or they are not tight.

Check and tighten the capillary connections.

There are dead volumes in the capillary connections.

Replace fittings.

Stamp seal is not tight.

There is air in the work head.

There is pump pulsation.

The gradient is reproducible.The gradient.Controller pumping function and extraction.

The test is unstable and degraded.

Use a new sample or change the conditions.Cool the sample in autosampler if possible.

View baseline turns "Baseline Swings"

The environmental conditions are unstable.

Make sure that the temperature and humidity are constant.

Pollution takes place somewhere in the system.

Rinse the system with a suitable solvent.

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Problem Truck Reason Remedy Actions

Noisy basin, high background stream

The mobile phase is polluted.

Use verse solvent.

Very withheld connections are elicated from the column.

This can occur when a new mobile phase or column is used.Leave the Økvilibre system for one hour with the new mobile phase or until the basic line is stable and checks the signal again.

Remove the column and the recovery of the current.If the signal falls, clean or replace the column (→ TCC manual).

Fittings delicious.

Pollution takes place somewhere in the system.

Rinse the system with a suitable solvent.

The detector is flooded with solvent (the pump current is switched on while there is no gas flow).

This can occur if the detector is eliminated.

Inability to signal

High background signal on a very sensitive power range (background> 10 x gain)

Use a mobile phase that offers a lower background (lower concentration of impurities).

Autozero is found at a peak or void signal.

Autozero on a relatively flat part of the Chromatogram.

Autozero on a very noisy signal.Reducer de Ruis or increase the current interval.

Liquid in the gas deplets The detector is flooded with solvent (the pump current is switched on while there is no gas flow).

This can occur if the detector is eliminated when liquid still flows into the detector.24 hours.

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8 maintenance

8.1 Security lines for maintenance

The following sections describe all maintenance procedures for the detector that the user can perform.

Warning: The liquid components of the device can be filled with solvents that are harmful to health.

Consult the material safety data sheet for the substance you use to complete the guidelines of Good Laboratory Practice (GLP) for information about the correct handling of a certain substance and for advice on specific dangers.

Warning: The liquid components of the instrument can be filled with harmful solvents.

For information about the correct handling of connections and recommendations for specific risk situations, contact the safety data of the medicines you use.

Before you start maintenance or service procedures, you must take the following precautions:

• For all service and repair procedures, view all caution statements that are specified in these business instructions.

• Only use the original spare parts that are authorized to the unit of Thermo Fisher Scientific.

See page 74 for instructions on closing the detector.

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8.2 Returns the detector for repair

Before returning the detector for repair, contact Thermo Fisher Scientific Service for Dionex HPLC products.Manual binder) when you send the detector.

If the original shipping container is not available, suitable shipping containers and packaging material from Thermo Fisher Scientific Sales Organization for Dionex HPLC products can be ordered.request.

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8.3 routine and preventive maintenance

8.3.1 Inspection OG Service Plan

The preventive maintenance functions of the detector offer information about internal parameters and service intervals.

Change gas filter Date of gas filter The date can be set manually.

1. Select Syste Menu Soft key in the main menu.

2. Select the date/time softkey in the System Settings menu.

3. Select Reset Filter CHG date Softkey.The detector is reset a 12 -month countdown.

Preventive maintenance date The date of preventive maintenance date (PM) contains information about the following preventive maintenance procedure and can be reset manually.

Tip: a service representative to carry out preventive maintenance for the detector annually.

To set the PM date from the detector screen:

1. Select Syste Menu Soft key in the main menu.

2. Select the date/time softkey in the System Settings menu.

3. Select Reset Next PM -DATO SOFT KEY.The detector reset a 12 -month countdown.

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General routine maintenance In an LC system carries out the maintenance procedures stated in the table with regular intervals to guarantee optimum performance and maximum uptime for the detector., rehearsal etc.

Frequency what to do ...

Investigate the daily power connections on indications of leakage or restrictions.

When using buffer solutions, the system thoroughly rinse a solvent after use that contains no buffers or salts.

Make sure that the solvent lesson (s) contains sufficient mobile phase for the expected analysis.

Regularly check the drainage pipes connected by the drainage gates at the bottom right of the detector (→ page 34).If necessary.

Investigate the hose for possible damage such as cracks, notches, cuts or blocking.

Check all electrical connections to ensure that they are in the right place.

Have a service representative check the detector annually and perform preventive maintenance once a year to prevent pollution and excessive wear.

The detector is only part of a chromatographic system..

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8.3.2 Maintenance of the detector between analyzes

Prevent the structure or accumulation of residues of mobile phase/analyzes within the detector between the analyzes.Best solubility characteristics for analyt (s) of the analytical method in question.

Remove the analytical column before performing one of the following washes procedures.

Mobile phase and color composition

Recommended Was procedure

Reverse phase (small molecules)

• A mixture of isopropyl alcohol (IPA) and HPLC quality water.The required amount depends on the gradient method used.

• High watery melanges when using buffers of more than 100 mm in strength.

Reverse phase (large molecules and polymers)

100 % Tetrahydrofuran (THF) or other suitable organic solvent as determined by the HPLC method used.

Reverse phase (proteins) A mixture of alcohol (IPA/methanol) and HPLC quality water (50:50).

Normal phase a mixture of tetrahydrofuran and methanol (50:50).

8.3.3 Cleaning of the surface of the detector

Note the following when cleaning the surface of the housing:

• Clean the surface of the detector with a soft towel that is moistened with a mild detergent.

• Prevent liquids from entering the detector because this can damage the detector.

If it is necessary to disinfect the cover surface, use a mild solution for 10 % bleach.With a soft towel.

8.3.4 Operational qualification and performance qualification

With operational qualification and performance qualification you can check and document the performance of the HPLC system.

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8.4 Removal of leakage

The Lekmut is installed on the inner panel of the detector (→ Fig. 2, page 19).

1. Stop the pump current.If you operate the detector of a chromatographic data system, couple the detector separately from the software.

2. Switch off the detector.

3. Investigate capillary connections on the detector for signs of leakage:

♦ reinforced control capillary connection with the needle for signs of leakage.

♦ Corona VEO RS Only Check the power -changing valve for signs of leaks on capillary connections of the column, with the nebulizer and to "deduce" (waste).

4. Absorb all liquid collected in the tray with a cloth or tissue.

Important: Make sure you do not bend or damage the sensor.

Important: Make sure you do not turn the sensor or damage it.

5. Take the sensor to adjust the ambient temperature for a few minutes.

6. Switch on the detector and connect it relevant to the chromatographic software.

7. If no errors are reported when you have switched on the detector, you can resume the operation.

Tip: if the sensor is not dry, the display still shows a warning code.

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8.5 Replacement of gas filters

The detector filters incoming gas through two gas filters: a carbon filter and a high -efficiency particle -shaped air filter (HEPA).

In the System Setup menu, under the Soft Key, the detector indicates when filters have to be replaced and warned if the date has expired..

To replace gas filters:

1. Stop detector processing:

A) Switch off the mobile phase flow.

b) Switch off the gas stream.

c) Switch off the gas supply to the detector.

D) Press the power switch on the rear panel of the detector to switch off the detector.

e) Disconnect the power cord from the most important power container of the detector.

Warning: Disconnect the detector from all power sources before the panels are removed.When the panels are removed, dangerous electrical connections are exposed.

Warning: Disconnect the detector from all electrical supply sources before the panels are removed.

2. On the right side of the detector, loose and remove the three screws that attach the tire plate to the detector housing with the Torx® TX 10 screwdriver.

Fig.24: replacement of gas filters

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3. Carefully move the cover plate away from the detector housing and place it close to the detector.

4. With the multi-tool from the accessory to the detector, push the charging ring on the push-in-mounting and carefully pull the gas hose.

5. Carefully pull the clamps on the cover plate.

6. To install the new filters, follow the above steps in reverse order.Install gas filters in the direction of the gas stream through filters.

7. Resnect the power cord to the most important power container.

8. Switch on the detector.Complete the notes and precautions in section 5.2 (→ Page 47).

9. On the detector screen, reset the replacement date of the gas filter in the System Settings menu.

a) Select Date to go to the Date and Time Setup screen.

b) Select Reset Filter CHG -DATO.

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8.6 Removal of the nebulizer

Important: even small particles can cause contamination for the nebulizer and can lead to poor detector performance.

Important: even small particles can cause pollution on the nebulizer and can lead to poor detector performance.Always white space gloves when installing or deleting the nebulizer to prevent contamination of detector components.

To remove the cloudy of the detector:

1. Stop detector processing:

A) Rinse all harmful solvents of the detector.For information about recommended washing procedures, see section 8.3.2 (→ Page 111).

b) Switch off the mobile phase flow.

c) Switch off the gas stream.Up to a few minutes to press the detector.

d) Switch off the gas supply to the detector.

e) Press the power switch on the rear panel of the detector to switch off the detector.

2. Remove the white lid on the right side of the front panel to gain access to the inner front panel.

3. In the opening of 90 degrees, turn the injector into the clock to unlock it.

4. Pull the injector from the opening in the inner front panel.

Warning: The melted silica capillair in the nebulizer sticks out of the atomizer.

Warning: The capillary of the silica melted in the nebulizer appears from the end of the nebulizer..

5. If you do not replace the injector, install the dust jacket on the opening of the injector on the front panel of the interior.

Consult the installation instructions to the nebulizer to install a new nebulizer.

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8.7 Stream-Switchingventil (Kun Corona Veo Rs)

Tip: When performing maintenance procedures on the valve power change, take a pair of gloves to clean spaces to prevent pollution of detector components.

8.7.1 Disassembly of the valve

1. Stop detector processing:

A) Rinse all harmful solvents of the detector.For information about recommended washing procedures, see section 8.3.2 (→ Page 111).

b) Switch off the mobile phase flow.

c) Switch off the gas stream.Up to a few minutes to press the detector.

d) Switch off the gas supply to the detector.

e) Press the power switch on the rear panel of the detector to switch off the detector.

f) Disconnect the capillaries from the power change valve.

2. Remove the main screws from the socket that attach the stator to the valve with a hexagonal key (9/64 "). Loosen the screws alternately: loosen each screw with only half a twist at a time to prevent the stator from becomingStuck.

3. Remove the stator from the clay body.

No description

1 valve

2 rotor

3 stator

Fig.25: Exploded view of the valve

4. Carefully remove the rotor seal with your hand or a small screwdriver.

5. Investigate the rotor and stator surfaces of scratches:

♦ If scratches are visible, the rotor and/or the stator must be replaced.

♦ If no scratches are visible, clean all parts thoroughly with dianized water and a microfiber cloth.

1 2

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8.7.2 Assembly of the valve

1. Place the rotor in the valve..

2. Install the stator on the valve.

3. Place the two socket head screws in the stator and the valve.Tighten them carefully until both are tightened.Close the cap against the clay body.

4. Re -message The Casillairaires To Nutrition Change the valve (→ Page 40).

5. Switch on the detector.Complete the notes and precautions in section 5.2 (→ Page 47).

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8.8 Replace the main effects

Warning: Switch off the main switch.

Warning: Before replacing the fuses, stop the detector.Sør to properly disconnect the sector sector.

1. Remove the pattern from the fuse with a small screwdriver.

Fig.26: Security pattern

2. Replace the two fuses.

Warning: Always install two fuses.

Warning: Always install two new fuses.

Description part nr.

Fuse, 1A, blow slowly (5 x 20 mm) included in Sires kit (part no. 70-6666) for information about the kit, see section 10.3 (→ page 127).

3. Reinstall the fuse patron.

4. Connect the power cord to the source.

Leak the patron

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8.9 Update the detector company

The detector is sent with the latest firmware version.Firmware version appears on the main menu screen.

To update the detector company, the Chromeleon Chromatography Management System is required.

To check which firmware version is installed in the detector and which version is included in Chromeleon:

• Open the Configuration Pages of the detector in the Chromeleon Server configuration program (→ Page 81).

• In Windows Explorer, search the IQreport.log file in the IQ folder in your Chromeleon installation.In the file, search for CAD3 FW (. Run file).

Tip: When you update the firmware via Chromeleon, this information is also provided under Download (→ below).

Every time a new firmware version is released in the detector, the new version receives the next release of Chromeleon service and described in the related release notes.

The new firmware is not automatically downloaded to the detector when you install a Chromeleon service release.Follow these steps to update the detector company:

Important: to ensure that download is successful, ensure that communication between the detector and Chromeleon is not interrupted during the download and the detector does not switch off.

Important: make sure that communication between the pump and Chromeleon is not interrupted and the instrument does not stop.

1. Check that before you start

♦ The detector is connected in Chromeleon.

♦ The Chromeleon server is in driving mode.

2. Start ServerKonFigationsProgrammet (→ Side 80).

3. Click on the detector in the time base and select properties in the menu.

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4. On the general page (→ page 81), the Firmware version of the detector in the Firmware field provided by Chromeleon.

5. Click Download.

Tip: if the detector comes with a newer firmware than the version in Chromeleon, downgrade the firmware

6. Click yes to start downloading.

The download can take a few minutes.

If download is not successful, the related messages appear in the audit track.In this case the detector will be re -elected.

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9 Technical information specification Corona Veo Corona Veo RS

Detection type charged aerosol -detection

Focus Jet ™ Concentric Flowdesign

Mobile phase current speed 0.2 - 2.0 ml/min 0.01 - 2.0 ml/min

Filter time constants 0.1, 0.2, 0.5, 1.0, 2.0, 3.6, 5.0, 10.0 seconds

Evaporation temperature eligible values: 35 ° C or 50 ° C

Settbart Interval: Environment +5 ° C TIL +100 ° C

Temperature accuracy <± 5 ° C

Balance time <30 minutes to 35.0 ° C evaporation temperature

Integrated Power Change klep

N. A.6 Poort 2 position valve (verifiable via TTL input)

Filtration of digital noise 4. Order Bessel filter with a low pass

Gas requirement compressed air or nitrogen

Manual electronic

Gasto suppression 480 - 550 kpa (70 - 80 psig)

Data collection Max.100 Hz (Chromeleon 6.80) Max.100 Hz (Chromeleon 6.80) or 200 Hz (Chromeleon 7)

User input/display Integrated liquid Crystal Color reproduction with touchscreen with menu functions

Software control available detector functions are software -driven via USB (USB 1.1 or 2.0 compatible).

Analog signal output (optional)

BNC Analog signal output

Analog output 0 - 1 V DC

Full scale analog output range

1 Tike up 500 2-2-5-5

Back Interface AC -STIK, Power Switch, USB -Port, Digitale I/O -terminals (4 TTL -inputs, 3 relaisuitjes)

I/O-limit surfaces 4 TTL inputs (gas from, Autozero, Start, Stream-Switching-valve), 3 relay outings (a fixed marked 'pump off')

Safety features Leksensor, liquid sensor, relief valve for guest print

Stream requirements 100-240 V AC, 50/60 HZ, 100 VA

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Specifikatie Corona I see Crown I see RS

Emission -sound pressure level <70 dB (A), usually 54 dB (A)

Environmental conditions User range of use: Use of use Temperature: 15 ° C to 35 ° C (59 to 95 ° F) Humidity: 80% Relative humidity, Non-condensing over-voltage category: II Pollution: 2

Wet parts Stainless steel (Type 316), Nitronic® 60 Stainless Steel, Peek, Simriz®, Aluminum, Samen Solica Corona Veo RS: PTFE (Valcon H, Valcon E)

Dimensions (H × W × d) 22.9 × 44.5 × 55.9 cm (9 × 17.5 × 22 inch)

Weight: about 14.3 kg (approximately 31.5 pounds)

Technical information: July 2013 All technical specifications can be changed without notice.

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10 accessories, consumables and accessories for spare parts, spare parts and consumables for the detector are always maintained on the latest technical standard.

For more information about accessories, consumables and spare parts, contact Thermo Fisher Scientific Sales Organization for Dionex HPLC products.

10.1 Standard accessories

The following standard accessories are sent with the detector.The part number always refers to the packaging unit.

10.1.1 I see crown

Description part no.Quantity in the accessory tax

Accessories for Corona Veo Detector

Facade set (2 fuses, 1A, Blowing slowly, 5 x 20 mm)

70-6666 1

Parts for draining the detector: T -piece for drain system L piece for drain system Flexible hose (11.4 mm o.d. x 8.4 mm i.d.)

Included in included in

6040.0005 6040.0005 6040.0005

2 4 2 m

Tool kit, including: 1 multi-tool 1 Offset Screwdriver Torx SIZE TX10 1 Offset Screwdriver Torx SIZE TX20 1 Screwdriver (3/32 "x 2") 1 Hexagon Socket Screw key (1/2 "x 9/16"))

6081.9190

Rheflex -Fittingen (Peek, 1/16 ", Vingertæt) recorded in 6000.0012 4 4

Inch-to-met-meter adapter (1/4 "o.d. up to 6 mm o.d.) --- 1

Exhaust hose massage, inclusive gas exhaust hose (1/2 "x 11/16" I.D. X O.D., L 2.5 m) Assembly (1/2 "x 3/8"))

70-6261 1

Gasinlaatbuizen (1/8 "x 1/4" I.D. X O.D., L 2,5 m) 6081.1070 1

In-line filter (SST) with filter-free recorded 70-4538 1

Filterfrites (SST, porosity 0.5 um) for replacement 70-4539 10

Pipe cut 70-7112 1

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Description part no.Quantity in the accessory tax

Kabel i/o, 2-Lader 70-4

USB-Kabel Type A TIL Type B, 3 M 70-5713 1 1

Capillair (I.D. X O.D. 0.005 "x 1/16", L 2 M, Peek), Red 6081.1410 1

Mober and fulous Rules, 1/4 ") -------------

Signal synchronization cable from LPG-3400RS pump to Corona detector

6043.0003 1

Signal cable (6-pin mini DIN) 6000,1004 1

10.1.2 Corona I see RS

Description part no.Quantity in the accessory tax

Accessories for Corona Veo RS -Detector

Facade set (2 fuses, 1A, Blowing slowly, 5 x 20 mm)

70-6666 1

Parts for draining the detector: T -piece for drain system L piece for drain system Flexible hose (11.4 mm o.d. x 8.4 mm i.d.), 2 m

Included in included in

6040.0005 6040.0005 6040.0005

2 4 1

Tool kit, including: 1 multi-tool 1 Offset Screwdriver Torx SIZE TX10 1 Offset Screwdriver Torx SIZE TX20 1 Screwdriver (3/32 "x 2") 1 Hexagon Socket Screw key (1/2 "x 9/16"))

6081.9190

Rheflex -Fittingen (Peek, 1/16 ", Vingertæt) recorded in 6000.0012 4 4

Inch-to-met-meter adapter (1/4 "o.d. up to 6 mm o.d.) --- 1

Exhaust hose joint, including gas outlet hose (1/2 "I.D. X 11/16" O.D., L 2.5 m) Assembly (1/2 "x 3/8"))

70-6261

Gasinlaatbuizen (1/8 "x 1/4" I.D. X O.D., L 2,5 m) 6081.1070 1

In-line filter (SST) with filter-free recorded 70-4538 1

Filterfrites (SST, porosity 0.5 um) for replacement 70-4539 10

Pipe cut 70-7112 1

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Description part no.Quantity in the accessory tax

Mober and fulous Rules, 1/4 ") -------------

Capillair (I.D. X O.D. 0.005 "x 1/16", L 2 M, Peek), Red 6081.1410 1

Capillair (0.015 "x 1/16" (i.d. x o.d.), l 1.5 m, peek), gray

6081.1420 1

Capillary (0.13 x 100 mm (i.d. x l), stainless steel, Viper) for connection between power change valve and atomizing.

6040.2322 1

Kabel i/o, 2-Lader 70-4

USB-Kabel Type A TIL Type B, 3 M 70-5713 1 1

Signal synchronization cable from LPG-3400RS pump to Corona detector

6043.0003 1

Signal cable (6-pin mini DIN) 6000,1004 1

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10.2 Optional accessories

Accessories description part no.

Analog Signal Extract Set -Kit contains all necessary parts for installing the analog output card with a BNC connector and installation instructions.

6081.0010

Viper Inverse gradient Capillary kit to Ultimate 3000 SD System

The kit contains all necessary parts for connections in an HPLC SD system and instructions.

6040.2819

Viper Inverse gradient capillary kit to Ultimate 3000 RS system

The kit contains all necessary parts for connections in an HPLC RS system and instructions.

6040.2820

Power splits for adjusting the liquid flow;

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10.3 Consumer substances and spare parts

The part number always refers to the packaging unit.Unless stated otherwise, the packaging unit 1 is unit.

Cables

Description part nr.

USB-Kabel Type A TIL Type B, 3 M 70-5713

Kabel i/o, 2-Lader 70-4

Signal synchronization cable from LPG-3400RS pump to Corona Detector 6043,0003

Signaal cable (6-pool mini DIN), 5 m 6000.1004

Capillarize

Description part nr.

Capillair (I.D. X O.D. 0.005 "x 1/16", L 2 M, Peek), Red 6081.1410

Capillair (0,015 "x 1/16" (I.D. X O.D.), L 1,5 M, Peek), Gray 6081.1420

Capillair, Viper (0.13 x 100 mm (i.d. x l), stainless steel) 6040.2322

Gascomponenten

Description part nr.

Gas filter unit, including 1 gas filter, coal 1 gas filter, Hepa

6081.7062

Gas inlet pipes, L 2.5 m 6081.1070

Gasuitlaatslang, L 2,5 m 70-6261

General spare parts

Description part nr.

Facade set (2 fuses, 1A, Blowing slowly, 5 x 20 mm) 70-6666

Filterfrites (SST, porosity 0.5 um) for use in in-line filter, 10 Frits 70-4539

Pipe cutter (1/8 "x 3/4") 70-7112

Tool kit, including: 1 multi-tool 1 Offset Screwdriver Torx SIZE TX10 1 Offset Screwdriver Torx SIZE TX20 1 Screwdriver (3/32 "x 2") 1 Hexagon Socket Screw key (1/2 "x 9/16"))

6081.9190

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Cut

Description part nr.

Nebulizer, FocusJet, for Corona Veo and Corona Veo RS 6081.1287

Power -instructions

Description part nr.

Nutrition cable, EU 6000.1000

Nutrition Cable, US 6000,1001

Power Cable, UK 6000.1020

Power Cable, Switzerland 6000.1030

Nutrition cable, Italy 6000.1040

Nutrition cable, Japan 6000.1050

Power Cable, Australië, China 6000.1060

Nutrition cable, Denmark 6000.1070

Power Cable, India/op 6000.1090

Stream-switching Ventildele (Kun Corona Veo Rs)

Description part nr.

Rotor to current change valve 6820.0014

Stator to Power Change Klep 6820.0012

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11 supplement

11.1 Digital I/O -PIN -Allocation The four TTL inputs and three relay exits on the rear panel on the detector offer the connection minals for external units.

See page 130 for more information about TTL inputs.

See page 131 for more information about relay outputs.

Digitale i/o -thermal to

Pin -signal name Signal level Note

1 CC1+ Relay output positive polarity

2 CC1 Relayout Put Negative polarity

3 GND Earth

4 cc2+ relay output positive polarity

5 cc2 relay output negative polarity

6 GND Earth

7 Divert+ TTL Input Positive Polarity

8 TTL -Input Negative Polarity by TTL

9 GND Earth

Fig. 27: Pin -tilding digitale I/O -terminal a

Digital i/o -terminal b

Pin -signal name Signal level Note

1 pump of+ relay output positive polarity

2 Pump Off-Relay Output Negative Polarity

3 GND Earth

4 Gas of+ TTL -Inang Positive Polarity

5 Gas or TTL input negative polarity

6 GND Earth

7 autozero + ttl input positiv polaritet

8 Autozero- TTL Input Negativ Polaritet

9 GND Earth

10 Start+ TTL -Inang Positive Polarity

11 starts input negative polarity

12 GND Earth

Fig.28: PIN -TILDING DIGITAL I/O TERMINAL B

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Important: when connecting TTL inputs, Shell 0.5 A.

Important: when connecting TTL -inputs

TTL -input the inputs are TTL compatible and get "Gas off", "Autozero", "Start" and "Divert".One is used.Change of TTL level, the tension must be between 0 and 5 V and the unity of the feeling of polarity must be matched (ie "+" and "-" to the external unity must be connected "and"-"of the detector). The "+" port is the top of each group, " -" Poort is immediately below, followed by the earth (GND).

• Start the "Start" input is available for use with a chromatographic data system that requires the activation of eventsnchronization to data collection from an external device, such as an autosampler.At least 0.5 seconds) of the external device.

• Gas from the "gas from" input can be used to switch off the internal gas inlet valve and to stop the gas supply to the nebulizer.

If the "Gas OFF" input is enabled, the detector closes the internal gas supply.

• Autozero "Autozero" input can be used to set the signal of a channel on a "zero point", regardless of the measured power.

Allow enough time after you have carried out Autozero and before injection to ensure that the Autozero assignment is completed.It is expected that reasonably flat (ie 15 seconds before the elution of a top).

• Give the "diversion" input can be used to control the power -changing valve with a driver for the third party.

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Relay outputs

"Pump OFF" output switch is used to send a signal to the pump (or other external device) to stop the power of mobile phase and switch off the pump.With a mobile phase if the gas pressure falls less than 50 % of the required gas volume for more than 60 seconds.To switch off the liquid flow.In some cases a special cable is required.

The pins with the "CC1" "" and "CC2" label offer contact closures that can be used to start an external device (for example, an autosampler) or to change a valve position. Output switches are used, connects the outputAccording to their polarity ("+" or "-").

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11.2 Internal Gas and Aerosolstroom Road diagram

The following diagram shows the gas and aerosol stream paths in the detector.

Fig.29: Gas and aerosol stream paths in the detector

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Operating instructions Page 133

12 Index

An accessory

Optional ...................................................... 126 Standard ................................................... ........... 123

Analog signal output .................................... 32

B Baseline Ruis ........................................................... .... 68 before operation ....................................................... .... 59

Detector ..................................................... ...... ........ 62 System .................................. ...... ................... 61

C Capillary connections ........................................ 39 Chromeleon......85

Automated check .................................... 88 batch ............................................................ .... ..... 89 change of configuration ................................ 84Assignments (dialog box) .... .......................... 86 Connect ................... ..... ................................... 85 Control Panel ....... ...... ................................... 87 program ...... ...... ............................... 88 detector configuration .............. ................ 81 detector installation ............................ .. 80, 84 Direct control ....................................... ........ .... 86 firmware download ........................................... 120 firmware -update ...... ........................................... 119 firmware version ........... ............................ 120 Installation program ...... .............. .................. 78 License................ .............. ............................ 85 panel table ..... .............. ............................... 87 program Start .. .............. ................................ 89 program -wizard............... ............................. 89 Server configuration program ... ............. 78, 80 Server monitor .................................... ............ 78.80 USB -Driver ... .................................... ................ 78

Chromeleon Dialogue Detector Page ..................................................... 82 General page ............................................. ........ 81 Relis page ............................................... ............ 83 signals page ....................................... ................... 83

Configurations (detector) .................................. 16 connections (rear panel)

Analog Signaaluite .................................... 32 Digital I/O ............ ... 29 Stretch Cord ............................................... ...... ...... 29 USB ........................................ ...... ..................... 30

Userability ..................................................... .... ... 127 check

Chromeleon ......................................................

D Data collection ....................................................... .... .................................................. ........ .............................................. ............ .... screenshot of time ......................................... 84 detector

Configurations .......................................... 16 description....................................................... .....

Detectorscherm ............................................................ 22 power-up .................................................. .

Detector drainage ........................................................ .. 34 detector reconciliation ........................................... 62 Detector Flood alarm .. ...... ........................... 72Diagnosis screen .............. ..... ......................... 52 Digital I/O

Installation ..................................................... .... ... 31 pin -task ................................................ ... 129 Relay -Releases .................................................... ...................................................... ................................................... .......................................................

Digital I/O -screen .................................................

Brightness ..................................................... .... 49 contacts and input screen ........................... 58 Date and time settings screen .... ...... ................. 57 Diagnostics ......................... ...... .................... 52 evaporation temperature screen .................. 54 gasRegulator screen ........ ........................... 56 Gran Screen .................... ........................... 53 Main menu ......... ............ .............................. 49 mode mode run ... ............ ......................... 50 System settings menu ....... ............. .................. 55

Display Control .........................................................

E error codes ....................................................... .... ........ 96 evaporation temperature .................................. 66 evaporation temperature screen ... ................... 54

F FILTERKONSTANT ............................................................... 66 Firmware

To retrieve.................................................... 119 update ................................................. ............ 119

Flow connections .................................... 21, 36 Flow Path Chart ......................... 79 security replacement ..........................

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G gas

Connections ..................................................... ............................... 71 Printing institution ................. ......................... 56

Gastrooms analytical .....................................................

Gas Stock ................................................

Great screen .....................................................

I in-line filter ................................................. ......... 38 Installation

In Chromeleon ................................................................ .. 27 connections of the rear panel ................................ 29

Intended use .................................................................

L Detection of leakage .................................................. ..... 70 Lekpoort .................................................... .......... 22, 70, 112

M Maintenance ............................................................ ... ..... 107

Between analyzes ........................................... 111Cleaning detector area....... ................... 111 firmware -update ........................... ............. 119 Inspection plan .................................. ......... 109 Intervals .................................... ....... ............... 109 Lepering sensor ......................... ........ ................ 112 replacement of fuses ...................... ........ ............ 118 replacement of gas filters ......................... ......... 113 security ............................................... ............ .......... 107

Manuel Gasregulator ........................... 21 Mobil -Fase ...... ........ ............................... 41

N nanoviper -capillaries ........................................ 37 amplifier .......................................................... .... ..... 21

Removal ..................................................... ..... 115

O Business guide ..................................... 1 operational principle .....

Stroompad diagram ........................................... 132 Operating problems ............................................. 99

Operation ........................................................... 45 detector display ......................................... ...... 22 General guidelines ........................................... 41 Power -so -high .................................................... ... ...... 47 security ............................................... ... ............ 45, 46 safety rules .............................. .... ........ 4

Operational qualification ............................ 111 Optimization ..................................................... 65

Baseline Ruis ........................................................ .. 68 Data collection speed ......................................... 69 evaporation temperature ... ...................... 66 Filter constant ...................... ........ ................ 66 Gas current status ...................... .......... ........... 67 guidelines ........................... .......... ................ 65 Power function value .................... ............ .. 68

P Parallel detector configuration ......................... 28 Performance -optimization ................................. 65 Performance qualification ............................... 111 positioning............................................................. 27 Power Connection ................................................. 29 Power -function value ....................................... 68OpStart .............................................................. 47 Forberdelse

Actions ..................................................... ......... 33 drainage ............................................... ................ 34 gas connections ....................................

Preventive maintenance ................................ 22

R BAGPANEL ..................................................................... 20

Digital I/O .................................................. ....... 31 returns the detector ...................................108 RMA number .......................................... .... 108 routine and preventive maintenance .............. 109

S Security ........................................................ ... ................... 3 security functions

Detector flood alarm .............................. 72 power ratio alarm ................ ......... 71 internal floating detection .............................. 70 leaking sensor ..... ......................................... 70

Security rules ........................................... 4 Test analysis.64 Self -test error codes....... ..................... 28 Close ........................... .............................. 74 site -Requirements ................................ 42 spare parts ....................... ........ ........................ 127 Specification ................ ........ ................................ 121 Start -Aacts ...... ............ .................................... 33

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Stream-Switching valve ........................................ 21 Montage .........Connections .... ................................................. .. 40 dismantling... 116 operation.......... .... 64

Symbols ..................................................... .... ................ 3 System preparation .................................... ............. 61

Technical information ...................................... 121 touchscreen control .......

Business problems .................................................99 Overview........ ................................................... ...... 91 fast controllers.............. .............................. 95

U Ultimate 3000

Capillaries ..................................................... .... 37 unpacking ................................................ ............. 26 USB ........................................... ................................ 30 USB -configuration file .............. ....................... 79

V Ventilation ........................................................ ... ......... 43 ventilation requirements .................................. 24 Viper -Capillaries...............................................

W Warning Codes ........................................................... ... 95 Wallhaven .....................................................

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